Barrett食管的酸反流类型

Patterns of acid reflux in Barrett's esophagus

目的：了解Barrett食管的发生与胃食管酸反流类型之间的关系。方法：对23例Barrett食管及37例反流性食管炎（Ⅱ级16例，Ⅱ、Ⅲ级21例）病人行24小时食管内pH监测。分别将直立位和卧位pH＜4的百分时间；反流次数；反流持续5分钟以上的反流次数；最长反流持续时间之间进行比较。结果：两组直立位时Ⅰ级食管炎组与Barrett食管比较，差异有显著性（P＜0．01，P＜0．01，P＜0．05，P＜0．01），Ⅱ、Ⅲ级食管炎组与Barrett食管比较差异无显著性（P＞0．05）。卧位时，无论是Ⅰ级食管炎还是Ⅱ、Ⅲ级食管炎组各指标与Barrett食管比较，差异均有显著性（P＜0．05，P＜0．001）．结论：卧位酸反流在Barrett食管的发病中可能起重要作用。

Objective:. Method: To determine the relatonship between Barrett's es-ophagus(BE) and patterns of gastroesophageal acid reflux. Method: We peformed 24h ambulatory esophageal pH monitoring in 60 patients who were divided into three groups: 16 with mild esophagitis and 21 with severe esophagitis, 23 with BE. The following parameters were evaluated as follows: the percentage time of pH＜4; the number of reflux episodes; the number of reflux episodes longer than 5 minutes; the duration of longest episodes in erect and supine position. Resultst: Our results showed: during erect position all the above parameters in BE patients were not significantly different from those with reflux esophagitis (P＞0.05), whereas in supine position in BE patients these differed significantly from those with reflux esophagitis (P＜0.05).Conclusion: Our study suggest that acid reflux in supine position might be important in the development of BE in GER.