醛糖还原酶抑制剂治疗糖尿病周围神经病变的临床观察

Clinical observation of aldose reductase inhibitor in diabetic peripheral neuropathy

目的:观察醛糖还原酶抑制剂依帕司他治疗糖尿病周围神经病变(DPN)的疗效。方法:DPN患者90例,随机分为治疗组46例(口服依帕司他片),对照组44例(肌肉注射维生素B12),记录治疗前后患者的主观症状、体征及肌电图检查神经传导速度的改善情况。结果:经8周治疗后,证明依帕司他对糖尿病周围神经病变自觉症状、体征及周围神经传导速度的改善有较好疗效,其疗效优于对照组,两组疗效差异有显著性。结论:醛糖还原酶抑制剂依帕司他治疗糖尿病周围神经病变是一种安全、有效的药物。

Objective：To observe the curative effect of diabetic peripheral neuropathy（DNP） by epalrestatas one of the aldose reductase inhibitors.Methods：90 patients with DPN were randomly divided into treatment group （46 cases by oral apphcation with epalrestat ） and control group （44 cases by intramuscular injection with vitamin B=）.Furthermoro ,the changes of subjective symptoms physical signs and nerve conduction velocity（NCV） were compared by electromyogram examination in two groups before and after treatment. Results ：The subjective symptoms physical signs and NCV in treatment group were significantly improved compared with those in control group. Conclusion：The epalrestat as one of aldose reductase inhibitors is a safe and effective drug for the treatment of diabetic peripheral neuropathy.