外周血及移植肾内嗜酸性粒细胞变化的临床意义

Blood and interrenal eosinophilia in the monitoring of acute rejection of the renal allograft

为了解移植肾在急性排斥时外周血和移植肾内嗜酸性粒细胞（ＥＯ）变化的意义，动态观察３１例同种异体肾脏移植病人的外周血和移植肾内ＥＯ的变化。结果发现在急性排斥反应时，移植肾内ＥＯ数＞２％者占８０．９％，明显高于肾功能稳定时，Ｐ＜０．０１；重度排斥中血ＥＯ数＞４％者占８２．６％，明显高于肾功能稳定时和中度以下排斥者，Ｐ＜０．０１。结果认为，测定移植肾内的ＥＯ变化可以做为监测急性排斥反应的可靠指标，外周血中的ＥＯ明显增多常提示排斥反应较为严重。

Peripheral blood and interrenal eosinophilia were examined in 31 cases of cadaveric renal transplant recipitents. In 80.9% samples, the percentage of interrenal eosinophilia was more that 2% during rejection episodes, significantly greater than that at stable renal function ( P <0.01). In 82.6% samples, the blood eosinophilia percentage was more than 4% in severe rejection, greater than that in light and mild rejection ( P <0.01). We concluded that interrenal eosinophilia is a reliable parameter for the monitoring of acute rejection. Greatly increased blood eosinophils usually shows an episode of serious rejection. The value of blood eosinophils in diagnosis of rejection should be studied further.