多肽自组装技术及其在生物医学上的应用

Self-assembly Peptide for Biomedicine Application

多肽分子自组装广泛存在于自然界中。多肽具有良好的生物相容性和可调控的降解性能,并且利用多肽自组装技术,可以在分子水平上设计并调控聚集态的形状和结构,这在生物医学材料方面具有巨大的应用潜力。近年来关于多肽自组装的研究成为材料学、医学等领域中研究热点之一,并且在药物缓释载体、组织工程支架研究方面取得进展。本文介绍多肽分子自组装技术的概念,综述了多肽自组装技术在药物缓释载体材料、组织工程支架材料方面的应用。

Peptide self-assembly is a popular phenomenon in nature. Peptide is an ideal biomaterial for its biocompatibility and controlled degradability. The key advantage of using peptide self-assembly is that building blocks self-associate in particular patterns to form higher order organized complexes which can be designed and engineered at the molecular level. Peptide self-assembly can be used in biomedicine. Recent years, peptide self-assembly is being researching in material sciencem, medicine and is applied as drug delivery system and tissue engineering scaffolds. This article focus on the basic principle of peptide self-assembly and its application in delivery carriers and scaffolds of tissue engineering.