新鲜羊膜移植治疗急症重度眼烧伤

Observations on the therapeutic effect of fresh amniotic membrane transplantation and emergency medical treatment in severe ocular burn

目的研究早期重度眼烧伤的急症处理,联合新鲜羊膜移植的临床效果。方法急症处理15例(18眼)眼烧伤,采用新鲜羊膜治疗碱烧伤4例(5眼),酸烧伤3例(4眼),铁水烫伤5例(5眼),热水烫伤3例(4眼)。结果18眼均无羊膜移植排斥反应和继发感染。术后无角巩膜溶解穿孔、虹膜萎缩,视力较前提高。12眼合并不同程度的角膜斑翳,4眼出现角膜新生血管,2眼全角膜浑浊行角膜移植术。结论运用正确的急症处理联合羊膜移植治疗眼表烧伤,可促进上皮细胞分化移行,抑制局部炎症发生,能有效阻止新生血管和瘢痕形成,预防睑球粘连。

Objective To investigate the effect of fresh amniotic membrane transplantation and emergency medical treatment in early stage of severe ocular burn. Methods 15 patients with ocular burn （18 eyes ） were treated with fresh amniotic membrane transplantation. 4 cases of severe alkali burn （5 eyes）, 3 cases of severe acid burn （4 eyes） and 8 cases of thermal burn （8 eyes） were inclued. Results In all eyes, there was no reject reaction observed. After surgery,corneal dissolution and iris atrophy were not found. There were 12 eyes with corneal macula and 4 eyes with corneal neovascular. 2 eyes were treated with corneal transplantation because of leucoma in most area of corneal. Conclusions Emergency medical treatment and amniotic membrane transplantation can promote the migration of epithelium cell, reduce local inflammation reaction, neovascularizaion and fibrosis.