通心贴对冠状动脉粥样硬化性心脏病患者血清Hs-CRP、IL-18、GMP-140的影响

Effects of "Tongxin Plaster" on Serum High Sensitivity Creactive Protein,Interleukin-18 and Granules Membrane Protein-140 in Patients with Coronary Heart Disease

目的观察通心贴对冠状动脉粥样硬化性心脏病(CHD)肾阳亏虚兼痰瘀内阻证患者冠状动脉炎症、血小板活化水平的影响。方法将80例CHD肾阳亏虚兼痰瘀内阻证患者随机分为两组,治疗组41例,膻中穴、心俞穴二穴交替贴敷通心贴,每穴贴敷12h/次,1次/d,治疗3周;对照组39例,采用麝香保心丸口服,每次2粒,3次/d,治疗3周。分别于治疗前后采集空腹静脉血,测定血清Hs-CRP、IL-18、GMP-140水平。结果两组治疗后血清Hs-CRP、IL-18、GMP-140水平均明显降低(P<0.01),其中治疗组Hs-CRP水平低于对照组(P<0.05)。结论通心贴具有抑制冠状动脉炎症反应,抑制血小板活化作用,这可能是其治疗冠心病肾阳亏虚兼痰瘀内阻证的机制之一。

Objective To study the effects of ＂Tongxin Plaster＂ on serum high sensitivity C reactive protein （Hs-CRP）, interleukin-18 （IL-18）, and granules membrane protein-140 （GMP-140） of patients with coronary heart disease （CHD）. Methods Eighty CHD patients were randomly divided into two groups： 41 cases in treatment group were given acupoint application of ＂Tongxin Plaster＂ on acupoint Tanzhong （CV 17） and Xinshu（BL 15）, 12 hours a day; 39 eases in control group were given orally ＂Shexiangbaoxin Pill＂, 2 pills twice a day. The treatment courses of the two groups lasted 3 weeks. The serum levels of Hs-CRP, IL-18 and GMP-140 were detected respectively. Results After 3 weeks of treatment, the levels of Hs-CRP, IL-18, GMP-140 in both groups all decreased significantly（P〈0.01）. The level of Hs-CRP was lower in treatment group than in control group（P〈0.05）. There was no significant difference in the levels of IL-18, GMP- 140 between the two groups （P〉0.05）. Conclusion ＂Tongxin Piaster＂ has good effects on antagonizing inflammatory response of coronary artery and inhibiting activation of platelets, which may be one of the mechanisms for ＂Tongxin Plaster＂ on CHD.