期刊文献+

脂联素与乳腺癌和子宫内膜癌关系的研究进展 被引量:13

下载PDF
导出
摘要 脂联素为脂肪细胞分泌的一种细胞因子,血浆脂联素低水平与胰岛素抵抗有关。而胰岛素抵抗综合征症患者的乳腺癌和子宫内膜癌的患病风险增高。有研究表明,乳腺癌和子宫内膜癌患者的血浆脂联素水平降低。脂联素不仅能影响血浆中的某些细胞因子水平而抑制癌症发生发展,而且能通过多种信号传导途径直接抑制肿瘤细胞增殖、促进凋亡。控制胰岛素抵抗,提高循环脂联素水平,为预防和治疗乳腺癌和子宫内膜癌提供新的思路。
出处 《国际妇产科学杂志》 CAS 2008年第2期117-121,共5页 Journal of International Obstetrics and Gynecology
  • 相关文献

参考文献20

  • 1[1]Qi L,Rimm E,Liu S,et al.Dietary glycemic index,glycemic load,cereal fiber,and plasma adiponectin concentration in diabetic men[J].Diabetes Care,2005,28(5):1022-1028.
  • 2[2]Calle EE,Kaaks R.Overweight,obesity and cancer.,epidemiological evidence and proposed mechanisms[J].Nat Rev Cancer,2004,4(8):579-591.
  • 3[3]Rose DP,Komninou D,Stepbenson GD.Obesity,adipocytokines,and insulin resistance in breast cancer[J].Obes Rev,2004,5(3):153-165.
  • 4[4]Inoki K,Ouyang H,Li Y,et al.Signaling by target of rapamycin proteins in cell growth control[J].Microbiol Mol Biol Rev,2005,69(1):79-100.
  • 5[5]Inoki K,Ouyang H,Zhu T,et al.TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth[J].Cell,2006,126(5):955-968.
  • 6[6]Goldstein BJ,Scalia R.Adiponectin:A novel adipokine linking adipocytes and vascular function[J].J Clin Endocrinol Metab,2004,89(6):2563-2568.
  • 7[7]Cong L,Gasser J,Zhao J,et al.Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells,HEC-1-A and RL95 2[J].Endocr Relat Cancer,2007,14(3):713-720.
  • 8[8]Miyazaki T,Bub JD,Uzuki M,et al.Adiponectin activates c-Jun NH (2)-terminal kinase and inhibits signal transducer and activator of transcription 3[J].Biochem Biophys Res Commun,2005,333(1):79-87.
  • 9[9]Brakenhielm E,Veitonmaki N,Can R,et al.Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis[J].Proc Nail Acad Sci U S A,2004,101(8):2476-2481.
  • 10[10]Dieudonne MN,Bussiere M,Dos Santos E,et al.Adiponectin mediates antiproliferative and apoptotic responses in human MCF7breast cancer cells[J].Biochem Biophys Res Commun,2006,345(1):271-279.

同被引文献110

  • 1刘霞,张为远,代荫梅.子宫内膜癌相关危险因素研究进展[J].中国全科医学,2009,12(12):1128-1131. 被引量:23
  • 2岳天孚.肥胖与子宫内膜癌[J].中国实用妇科与产科杂志,2004,20(12):712-713. 被引量:3
  • 3杨丹,韩立敏.1969-2003年子宫内膜癌发病率及发病因素分析[J].复旦学报(医学版),2005,32(4):479-480. 被引量:33
  • 4于明月,张扬,边树怀.脂联素研究进展[J].疑难病杂志,2006,5(3):230-232. 被引量:9
  • 5王虹,刁清,周敬.代谢紊乱患者脂联素水平和血管内皮细胞功能的变化[J].疑难病杂志,2007,6(6):327-329. 被引量:5
  • 6Kumor A,Daniel P,Pietruczuk M,et al.Serum leptinadiponectin,and resistin concentration in colorectal adenoma and carcinoma (CC) patients[J].Int J Colorectal Dis,2009,24(3):275-278.
  • 7Cust AE,Kaaks R,Friedenreich C,et al.Plasma adiponectin levels and endometrial cancer risk in pre-and postmenopausal women[J].J Clin Endocrinol Meta,2007,92(1):255-263.
  • 8Soliman PT,Wu D,Tortolero-Luna G,et al.Association between adiponectin,insulin resistance,and endometrial cancer[J].Cancer,2006,106(11):2376-2381.
  • 9Petridou E,Mantzoros C,Dessypris N,et al.Plasma adiponectin concentrations in relation to endometrial cancer:a case-control study in greece[J].J Clin Endocrinol Meta,2003,88(3):993-997.
  • 10Rzepka-Górska I,Bedner R,Cymbaluk-Ploska A.Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women[J].Eur J Gynaecol Oncol,2008,29(6):594-597.

引证文献13

二级引证文献39

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部