可乐定对大鼠皮层体感诱发电位的影响

The inhabitative effect of clonidine on the somatosensory evoked cerebral potential

目的:用记录大鼠大脑皮层SEP的方法研究盐酸可乐定的镇痛作用。方法:SD大鼠分为对照组和可乐定组。对照组大鼠8只,腹腔注射生理盐水1ml;可乐定组15只大鼠,腹腔注射盐酸可乐定10μg(1ml)。记录两组注药前和注药后20、40、60分钟的SEP波形,并根据SEP的N15-P25峰-峰振幅推算镇痛率(即疼痛减轻率)。结果:对照组注药前后SEP振幅和潜伏期无明显变化。可乐定组注药后SEP振幅显著抑制和潜伏期明显延长,以20～40分钟达高峰,与疼痛相关性最强的N15-P25峰-峰振幅的镇痛率达80.6％。结论:可乐定有确切的镇痛作用。

Objective:The somatosensory evoked cerebral potential (SEP)was used to assess the analgesia effect of clonidine. Method: Twenty-three SD rats was randomly divided into two groups, the control group (n=8) and clonidine group (n=15). The control group rats was injected 1 ml normal saline to peritoneal cavity and the clonidine group rats was injected 10mg(1ml) clonidine peritoneally. The SEP waves were recorded in both groups at preinjection and 20,40,60 min after injection. Pain relief ratio was calculated according to the N15-P25 peak-peak amplitude of SEP wave. Result:SEP amplitude and latency were markedly reduced in clonidine group and remained unchanged in control group. The peak Pain relief ratio was 80. 6％at 20-40 min after clonidine administration. Conclusion:Clonidine does have a effect of pain relief