摘要
目的:观察心脏含血停搏液加入还原型谷胱甘肽在心脏瓣膜置换术中的心肌保护作用。方法:30例心脏瓣膜置换术患者随机分为两组,实验组(n=15)在心脏含血停搏液中加入还原型谷胱甘肽(剂量600 mg),对照组(n=15)单用心脏含血停搏液,分别经主动脉根部或切开主动脉经冠状动脉窦直接灌注,两组分别于麻醉诱导后、主动脉开放后2 h、6 h、24 h采集患者静脉血,测血清肌酸激酶MB同工酶(CK-MB)、乳酸脱氢酶(LDH)、心肌肌钙蛋白I(cTnI)。结果:两组主动脉开放后血清CK-MB、LDH、cTnI均较麻醉诱导后显著升高,实验组主动脉开放后的血清CK-MB、LDH、cTnI均较对照组显著降低(P均<0.05～0.01),差异均具有统计学意义。结论:还原型谷胱甘肽加入心脏停搏液中具有良好的心肌保护作用。
Objective： To observe the clinical effects of cardioplegia with reduced glutathion（GSH） in heart valve replacement surgery, Methods： Thirty patients with heart valve replacement surgery were randomly divided into two groups. GSH group（n=15 ）received GSH in cardioplegia solution, and control group（n=15）received cardioplegia alone. CK-MB, LDH,and eTnI were detected at various time points during cardiopulmonary bypass（CPB）. Results： The values of CK-MB, LDH and cTnI in GSH group after CPB were significantly lower than those in control group at different time points（P〈0.05-0.01）.Conclusion： Antegrade intermittent blood cardioplegia with GSH is effective for myocardial protection during heart valve replacement surgery.
出处
《中国循环杂志》
CSCD
北大核心
2008年第1期50-52,共3页
Chinese Circulation Journal
关键词
还原型谷胱甘肽
体外循环
心肌保护
Glutathione
Cardiopulmonary bypass
Myocardial protection
