Ⅱ型糖尿病辨证分型与血清超氧化物歧化酶、丙二醛的关系

Study on Syndrome-Type in TCM and Its Correlation with Superoxide Dismutase and Malonyldialdehyde in Patients with Non-Insulin Dependent Diabetes Mellitus

目的：探讨Ⅱ型糖尿病（ｎｏｎ－ｉｎｓｕｌｉｎｄｅｐｅｎｄｅｎｔｄｉａｂｅｔｅｓｍｅｌｌｉｔｕｓ，ＮＩＤＤＭ）中医证型与脂质过氧化反应之间的关系。方法：测定了６１例不同中医证型ＮＩＤＤＭ患者血清超氧化物歧化酶（ＳＯＤ）活力与丙二醛（ＭＤＡ）含量，并与２０名健康者作对照比较。结果：ＮＩＤＤＭ组比对照组ＳＯＤ活力明显降低（Ｐ＜０．０１），ＭＤＡ含量明显升高（Ｐ＜０．０１）；随阴虚热盛、气阴两虚、阴阳两虚证型顺序或无血瘀兼证到有血瘀兼证顺序，患者ＳＯＤ活力逐步降低，ＭＤＡ含量逐步升高。结论：ＮＩＤＤＭ患者体内抗氧化能力下降，脂质过氧化反应增强，这与中医证型有密切关系，通过检测患者血清ＳＯＤ与ＭＤＡ可为辨证分型作参考并可作为判断病情轻重的一项客观指标。

Objective: To explore the possible relationship between Syndrome-Type in TCM and the superoxide dismutase (SOD) as well as malonyldialdehyde (MDA). Methods: Serum SOD and MDA were measured in 61 patients with non-insulin dependent diabetes mellitus (NIDDM) and 20 normal subjects. Results: SOD activity of the NIDDM patients blood were clearly lower than those of normal subjects, but MDA were markedly elevated. From the Syndrome-Type of Yin Deficiency with Hyperactivity of Heat, to both Qi and Yin Deficiency, to both Yin and Yang Deficiency, or from without hemostasis to with the appearance of hemostasis in order. The SOD activity decreased and meanwhile MDA increased gradually. Conclusions: SOD activity and MDA levels in patients with NIDDM were associated with Syndrome-Type in TCM, it might be responsible for the diagnosis of Syndrome-Type in TCM.