摘要
目的:探讨补阳还五汤防治经皮腔内冠脉成形术(PTCA)后再狭窄的消长机制。方法:仿PTCA术后再狭窄的新西兰兔模型28只,以原位引物标记法测动脉内皮钢-锌超氧化物歧化酶(SOD-1)及血小板行化生长因子受体(PDGFR)的基因表达,分析再狭窄消长机理。结果:主动脉球囊扩张术后7天,手术部位动脉内皮的SOD-1基因表达增强,与对照组有显著差异(P<0.05),而PDGFRmRNA的表达则减弱,与对照组也有显著性差异(P<0.05)。结论:补阳还五汤增强动脉内皮SOD-1的基因表达,改善缺血再灌注的供氧。同样情况下,补阳还五汤抑制PDGFRmRNA表达,以控制细胞的病理性增殖。
Objective: To study on dynamic mechanism of restenosis after PTCA treated with Buyang Huanwu Decoction (BYHWD). Methods: Twenty-eight male New Zealand rabbits with mimic restenosis after aortic artery dilatation were detected by prime in situ labeling in aortic endothelium. The items included gene expression of copper-zinc superoxide dismutase (SOD-1 ) and platelet-derived growth factor receptor (PDGFR) mRNA to analyse dynamic mechanism of restenosis. Results: Seven days after aortic artery dilatation, PDGFR mRNA of aortic endothelium decreased clearly. The comparison between experimental and the control group showed significant difference (P <0. 05). By the same condition, the gene expression of SOD-1 was increasing, which showed a significant difference with the control group (P < 0. 05). Conclusions: BYHWD increased SOD-1 gene expression of artery endothelium,to improve oxygen feed for ischemia reperfusion in the same way, BYHWD suppressed PDGFR mRNA expression to control cellular pathological proliferation.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第10期611-613,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金
关键词
补阳还五汤
生长因子
冠状动脉狭窄
血管成形术
Buyang Huanwu Decoction
platelet-derived growth factor
copper-zinc superoxide dismutase
gene expression