泰素抑制涎腺腺样囊性癌远处转移的机制研究

An Study on Taxol against the Metastasis of Salivary Adenoid Cystic Carcinoma

目的:观察泰素(Taxol)对涎腺腺样囊性癌细胞远处转移的作用及其对肺转移灶血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP-9)表达的影响。方法:用涎腺腺样囊性癌肺高转移细胞株(ACC-M)裸鼠肺转移模型观察泰素体内抗转移效果,免疫组化法检测转移灶肿瘤细胞VEGF和MMP-9的表达。结果:对照组与Taxol治疗组相比,2组之间瘤结节数差异有统计学意义(P<0.05);Taxol治疗组VEGF及MMP-9表达明显弱于对照组(P<0.05)。结论:泰素对涎腺腺样囊性癌肺转移有较好的抑制效果,这可能与其抑制血管生成及基质金属蛋白酶表达有关。

Objective： To study the effect of taxol on experimental metastasis of ACC-M and the expression of VEGF and MMP-9 in vivo. Methods： The antimetastasis effect of taxol was studied in vivo experiments using nude mice model of pulmonary metastasis with ACC-M cell line. The expression of VEGF and MMP-9 of the lung metastases were also observed. Results： The numbers of pulmonary metastases was significantly reduced in treatment group （P 〈 0.05 ）. The levels of VEGF and MMP-9 positive expression were decreased in treatment group （P 〈 0.05）. Conclusion： Taxol has a strong antimetastasis effect on experimental metastasis of ACC-M. This may be relative to the inhibiting of the expression of VEGF and MMP-9 and vascular growth.