4Jacobson MA. Valaciclovir(BW256U87): The L - Valyl Ester of Acyclovir.J Med Virology, 1993, (Suppl)150 ～ 153.
5Lawton JS, Seabert, On N, et al. Absolute Bioavailability and Metabolie Disposition of Valaciclovir, the L - Valyl Ester of Acyclovir, following Oral Administration to Humans. Antimicrobial Agents and Chemotheryapy, 1995;39:2759 ～ 2764.
6Pharmacokinetics and safety of multiple - dose valaciclovir in geriatric volunteers with and without concomitant diuretic therapy. Antimicrobial Agents and Chemotherapy, 1996,40( 1 ): 80 ～ 85
7王萍.万乃洛韦对小动物急性毒性的研究(新药申报资料)[Z].
8陈鸿珊.万乃洛韦在小鼠体内对单纯疱疹毒感染的治疗效果(新药申报资料)[Z].
9Beauchamp LM, Orr GF, de Miranda P, et al. Amino acid ester prodrugs of acyclovir. Antiviral Chem. hemother. 1992,3(3): 157
10Weller S, Blum MR, Doucette M, et al. Pharmacokinetics of the acyclovir pro- durg vlalaciclovir after escalating single and multipledose administration to normal volunteers. Clin Pharmacol. Ther, 1993,54:595
