抗蛇毒中草药拮抗ET-1和S6b作用的初步研究

A Primary Study on Antagonizing Effects of Anti snake Venom Chinese Herbs on Endothelin 1 and Sarafotoxin 6b

通城虎、红背丝绸、徐长卿和东风菜醇提物口服给药，对ＥＴ１和蛇毒Ｓ６ｂ引起小鼠急性死亡有明显的保护作用；部分水提取物有相似效果；其醇提物对ＥＴ１引起的主动脉环收缩有明显的拮抗作用，提示中草药中具有拮抗ＥＴ１的活性成分。

Some anti snake venom Chinese herbs were used to test the antagonizing effect on ET 1 and S6b.Oral administration has shown that both the water and alcohol extracts from Cissus assamica and Aristolochia fordiana ,and the water extracts from Desmodium microphyllum,Cynanthum paniculatum and Polygonum cillinerve are very helpful in reducing the acute death caused by ET 1 and S6b(iv),while the extracts from Cissus assamica ,Aristolochia fordiana and Cynanthum paniculatum can dilate the vasoconstriction by ET 1 in a dose dependent manner.Pharmacodynamic parameters have shown that the potencies of alcohol extracts from Cissus assamica and Aristolochia fordiana are greater than that of Cynanthum paniculatum.These data suggest that traditional anti snake venom herbs have antagonizing effects on ET 1.