甲状腺功能异常对患者焦虑、抑郁情绪的影响

Effect of thyroid function on the status of anxiety and depression in patients with thyroid dysfunction

目的:了解甲状腺功能异常患者的情绪状况特点,分析甲状腺激素水平与情绪的关系。方法:测定32名甲状腺功能亢进患者、25名甲状腺功能减退患者和30名正常对照组的血清FT3、FT4及TSH水平,并用HAMA及HAMD量表进行评定。比较各组的焦虑、抑郁水平;分析甲状腺功能与HAMA、HAMD量表总分的相关性。结果:甲亢组、甲减组的HAMA、HAMD总分与正常对照组比较差异有统计学显著性(P<0.01)。甲亢组FT4与HAMD总分呈正相关(P<0.05)。结论:甲状腺功能亢进与甲状腺功能减退患者较正常对照组的焦虑、抑郁症状严重;甲状腺功能亢进患者抑郁症状的发生与甲状腺功能状况有相关性,改善甲状腺功能状况有助于患者焦虑、抑郁情绪的缓解。

Objective：To study the features of the emotional status of patients with thyroid dysfunction and analyze the relationship between levels of thyroid hormone and the emotion status. Methods：The levels of FT3,FT4 and TSH of 32 patients with hyperthyroidism,25 patients with hypothyroidism and 30 healthy persons（as normal control group） were measured. And Hamilton Anxiety Rating Scale（HAMA） and Hamilton Depression Rating Scale（HAMD） were used for evaluation of emotion status. The status of anxiety and depression in all groups were compared and the relationship between thyroid function and total scores of HAMA and HAMD were also analyzed. Results：There was statistical significant difference between the total scores of HAMA and HAMD in the hyperthyroidism group and hypothyroidism group and those of the normal control group（P〈0.01）. FT4 levels are positively correlated with total scores of HAMD（P〈0.05） in the hyperthyroidism group. Conclusions：The Anxiety and depression symptoms were more severe in patients with hyperthyroidism and hypothyroidism than the healthy adults. There was correlation between the occurrence of depression and thyroid function in patients with hyperthyroidism. Thus improving thyroid function will help to relieve anxiety and depression emotion in the patients with thyroid disorders.