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TRAIL及其受体的研究进展 被引量：2

Role of TRAIL and its Receptors in Apoptosis of Tumor
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摘要 肿瘤坏死因子相关的凋亡诱导配体(TRAIL)是肿瘤坏死因子超家族成员之一,能选择性诱导多种肿瘤细胞系的凋亡,而对正常细胞没有作用。TRAIL通过活化Casepase或线粒体依赖的途径诱导细胞凋亡。这种凋亡信号可以被其诱骗受体(DcR)所阻断,并且受Bcl-2家族蛋白所调节。本文将介绍TRAIL诱导凋亡的信号传导途径以及TRAIL的临床应用。 Tumour necrosis factor（ TNF）-related apoptosis-inducing ligand（TRAIL） is a member of the TNF superfamily which selectively induces apoptosis in a broad range of cancer cell lines, but not in many normal cells. TRAIL induces apoptosis by activating Caspases and the mitochondrial-dependent apoptotic pathway. Cell death induced by TRAIL can be blocked by a dominant-negative TRAIL receptor, decoy receptors（DcR）, and is regulated by members of the Bcl-2 family of proteins. This review is focused on the apoptotic signaling pathways regulated by TRAIL and summarizes what is known about their clinical role.
作者 陈文明
机构地区 首都医科大学附属北京朝阳医院血液与肿瘤科
出处 《首都医科大学学报》 CAS 2008年第2期109-112,共4页 Journal of Capital Medical University
关键词 TRAIL 肿瘤坏死因子相关的凋亡诱导配体 诱骗受体 BCL-2家族蛋白 诱导细胞凋亡 信号传导途径 肿瘤细胞系 选择性诱导
分类号 R392.11 [医药卫生—免疫学] R392.12 [医药卫生—免疫学]
  • 相关文献

参考文献12

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二级参考文献21

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共引文献7

同被引文献17

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引证文献2

二级引证文献19

首都医科大学学报
2008年 第2期

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