疾病家庭聚集性研究中对照的选择及其影响

SELECTING CONTROL GROUPS FOR STUDIES OF FAMILIAL AGGREGATION AND ITS INFLUENCE

本文讨论了疾病家庭聚集性研究中不同对照的特点。揭示在没有混杂因素作用的情况下，两种对照的任一种都可以通过与病例组比较，对疾病的家庭聚集性作出检验。但用指示对照有关的个体组成的对照具有较大的检验效能。若存在混杂因素，需采用分层分析方法或者标准化法对其进行控制，然后通过病例组与对照组的比较，对疾病的家庭聚集性作出推断。

This paper discussed the characters of control groups in familial aggregation studies,it appears either two of types of control groups are general used:(1)a control of group consisting of random sample from the population or (2)a control group consisting of relatives of individuals without disease.Both types of control group will give a valid test of the null hypothesis of no familial aggregation when there are no confounding factors,however tests using control group consistiong of relatives of individuals without disease will always be more efficient statistically.When there are confounding factors in studies,the influence of confound factors should be eliminated using the methods of standardization or stratified analysis,then making inference of familial aggregation of disease according to comparing rate of disease between case group and control group.