血液灌流治疗急性有机磷农药中毒临床研究

Clinical Study on Hemoperfusion in Patients with Organophosphorus Pesticides Poisoning

目的应用血液灌流(hemoperfusion,HP)治疗急性有机磷农药中毒(acute organophosphorus pesticides poisoning,AOPP)观察其临床意义。方法39例急性有机磷农药中毒患者分为两组。治疗组:急性重度AOPP中毒20例,在其他综合治疗的基础上及时行床边血液灌流治疗,观察血胆碱酯酶(choline esterase,chE)的变化及治疗效果。对照组:同期收治的因为非医疗原因未能行HP治疗的19例重度AOPP,比较观察两组chE恢复时间、脱呼吸机时间、并发肺部感染、住院时间、成活率、住院费用。结果与对照组相比,HP治疗组chE恢复时间快、脱机时间早、成活率高、住院时间短、总住院费用少。结论血液灌流对于急性药物中毒有良好疗效。

Objective To explore the clinical effect of hemoperfusion （HP） in patients with acute organophosphorus pesticides poisoning（AOPP）. Methods 39 patients with AOPP were devided into two groups. Treatment group ：20 patients with acute organophosphorus pesticides poisoning were treated with hemoperfusion on basis of other medical therapies. Observe the change of choline esterase （chE） and the therapeutic effects. Control group： 19 patients with severe AOPP cannot be treated by HP at the same time. Compare the two groups according to the following part ： the recovering time of chE, offline time, concurrent lung infect, time in hospital, survival rate, hospital fees. Results After comparison, HP group has quicker chE recovering time, earlier offline time, higher survival rate, shorter time in hospital and less hospital fees. Conclusion Hemoperfusion is effective to the patients with acute medical poisoning.