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FasL在睾丸细胞的定位 被引量：4

Localization of FasL in the Testicular Cells
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摘要 FasL/Fas系统介导的胞外信号凋亡途径是哺乳动物睾丸生殖细胞凋亡的一条主要途径,然而,关于FasL在睾丸细胞中的定位却存在争议。本文对近年来国内外关于FasL在睾丸中的细胞定位研究进行了综述,为阐明FasL/Fas系统介导生殖细胞凋亡的机制提供资料,对深入理解睾丸中Sertoli细胞和生殖细胞间的调控关系及临床实践具有一定的指导作用。 The Fas/FasL-mediated pathway is well recognized in germ cell apoptosis in the mammalian testis. However the cellular location of FasL in testicular cells remains ambiguous. The present paper briefly reviews the recent researches concerned with cellular location of FasL in the testis. Hopefully, it could provide useful information for further investigation in clarifying the mechanism of the Fas/FasL-mediated germ cell apeptosis during spermatogenesis and in its clinical practice.
作者 余秀琴 张衍泉 朱宝长
机构地区 首都师范大学生命科学学院
出处 《中国比较医学杂志》 CAS 2008年第4期73-77,共5页 Chinese Journal of Comparative Medicine
关键词 细胞定位 生殖细胞 Cellular localization, FasL Apeptosis Germ cell
分类号 R329.28 [医药卫生—人体解剖和组织胚胎学]
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参考文献42

  • 1Lee J, Richburg JH, Younkin SC, et al. The Fas system is a key regulator of germ cell apoptosis in the testis [ J ]. Endocrinology, 1997, 138:2081 - 2088.
  • 2Lee JW, Richburg JH, Shipp EB, et al. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis [J]. Endocrinology, 1999, 140:852 - 858.
  • 3Richburg JH, Nanez A., Gao H. Participation of the Fas-signaling system in the initiation of germ cell apoptosis in young rat testes 'after exposure to mono-( 2-ethylhexyl ) phthalate (MEHP) [ J ]. Toxicol Appl Pharmacol, 1999, 160:271-278.
  • 4Pentikainen V, Erkkila K, Dunkel L. Fas regulates germ cell apoptosis in the human testis in vitro [J]. Am J Physiol, 1999, 276: E310- E316.
  • 5Suda T, Takahashi T, Golstein P, et al. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family [J]. Cell, 1993, 75:1169 - 1178.
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二级参考文献8

  • 1孙晓青 赵鸿 等.抗排斥反应中睾丸Sertoli细胞与免疫抑制剂的协同作用[J].中华微生物学和免疫学杂志,2001,21:259-260.
  • 2Korbutt GS, Elliott JF, Rajotte RV. Cotransplantation of allogeneic islets with allogeneic testicular cell aggregates allows long-term graft survival without systemic immunosuppression. Diabetes, 1997, 46:317-322.
  • 3Lan P, Zhan W, Wang J, et al. Immune privilege induced by cotransplantation of islet and allogeneic testicular cells. Chin Med J, 2001, 114:1026-1029.
  • 4Takeda Y, Gotoh M, Dono K, et al. Protection of islet allografts transplanted together with Fas ligand expressing testicular allografts. Diabetologia, 1998, 41:315-321.
  • 5Suarez-Pinzon W, Korbutt GS, Power R, et al. Testicular Sertoli cells protect islet β-cells from autoimmune destruction in NOD mice by a transforming growth factor-β1-dependent mechanism. Diabetes, 2000, 49: 1810-1818.
  • 6Luca G, Calvitti M, Neri LM, et al. Mitogenic effects of rat Sertoli cells on adult homologous islet β-cells: in vitro and in vivo studies. Transplant Proc, 2001, 33:681-682.
  • 7陈创奇,兰平,詹文华.Fas-FasL系统在胰岛移植中的研究[J].世界华人消化杂志,1999,7(5):422-423. 被引量：5
  • 8陈创奇,詹文华,汪建平,蔡世荣,兰平,吴小剑,贺德.多种分离纯化大鼠胰岛细胞的实验方法比较[J].中山医科大学学报,2002,23(2):118-120. 被引量：13

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中国比较医学杂志
2008年 第4期

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