吲哚美辛对梗阻性黄疸患者血流动力学的调节作用

The regulation on hemodynamic of obstructive jaundice with indomethacin

观察６４例梗阻性黄疸患者和３９例单纯胆囊结石（Ｃ组）患者血流动力学变化及吲哚美辛的调节作用。梗阻性黄疸患者分为非吲哚美辛组（Ａ组）和吲哚美辛组（Ｂ组）。结果表明Ａ组每博量、心输出量和心脏指数显著高于Ｃ组（Ｐ＜００１），平均动脉压（ＭＡＰ）、周围血管阻力（ＳＶＲ）和门静脉血流速度（ＰＶＢＦ）显著低于Ｃ组（Ｐ＜００１）。Ｂ组术前ＭＡＰ，ＳＶＲ和ＰＶＢＦ显著高于Ａ组（Ｐ＜００１），Ｂ组术后上述指标进一步改善，但与Ｃ组比较仍有显著差异（Ｐ＜００１）。本组结果显示，术前口服吲哚美辛有改善梗阻性黄疸患者循环功能、门脉血流和肝功能作用。

Hemodynamic changes and regulations of indomethacin have been studied in 64 patients with obstructive jaundice and 39 patients with simple gallstones (group C) Obstructive jaundice patients were divided into non indomethacin group (group A) and indomethacin group (group B) The results showed that stroke volum,cardiac output and cardiac index were significantly higher in group A than those in group C( P <0 01),and mean artery pressure (MAP),stroke vessel resistance (SVR) and portal vein blood flow (PVBF) were obviously lower in group A than those in group C ( P <0 01) MAP,SVR and PVBF were obviously higher in group B preperation than those in group A ( P <0 01) and circulation function had been further improved post operatively in group B The results indicated that indomethacin can improve circulation function,PVBF and liver function in the obstructive jaundice patients