彩色超声对甲氨蝶呤联合米非司酮治疗未破裂型输卵管妊娠的疗效观察

To observe the effect of MTX and mifepristone to treatment unruptured ecctopic pregnancy with color uitrasonography.

目的应用彩色超声对未破裂型输卵管妊娠保守治疗中监测观察甲氨蝶呤（MTX）联合米非司酮治疗的疗效。方法50例未破裂型输卵管妊娠患者，以单用MTX治疗的20例为对照组，MTX联合米非司酮治疗的30例为观察组，对两组分别于服药前及服药后连续动态观察异位妊娠组织及包块的形成、发展与转归。比较包块缩小、症状消失时间，管形蜕膜排出情况，血与尿HCG2周下降率及达治愈标准时间。结果观察组治愈26例，治愈率86.7％，无效4例；对照组治愈13例，治愈率65.0％，无效7例。两组相比较，有显著性差异（P〈0．05）。结诊联合用药优于单用MTX,彩色超声可用于治疗该病的全程观察。

objective To observe curative effect of unruptured ectopic pregnancy treated by MTX and mifepristone with color ultrasonography. Methods 50 patients were divided into MTX group（ control group, n=20） and MTX ＋ Mifepristone group （observing group, n=30）. To dynamic observing evolution and outcomes of the fallopian tube ectopic pregnancy and embryo masses with color ultra sonography before and after conservation treatment . To compare with time of disappearing embryo masses, disappearance to symptom, reduction of HCG in urine or blood in two week and time of cure. Results 26 patients were cured in observing group . The rate of cure was 86.7% , 4 patients failed. 13 patients were cured in control group ,The rate of cure was 65.0% , 7 cases failed. To compare, they were significant difference （P〈0.05）. Conclusion MTX ＋ Mifepristone has an advantage of MTX in the conservation treatment of unruptured ectopic pregnancy. Color ultrasouography can be used to observation in the conservation treatment.