阻断乙肝病毒母婴传播的临床研究（附56例分析）

Clinical study on surgical interruption of hepatitis B virus maternal-neonatal transmission in 56 cases.

目的探讨乙肝病毒母婴垂直传播的阻断疗法临床意义。方法乙肝表面抗原阳性的孕妇从产前3个月开始注射乙肝免疫球蛋白200IU，每月一次，总共3次。新生儿出生后立即注射乙肝免疫球蛋白200IU，15d再注射一次。同时与乙肝疫苗联合应用，接种乙肝疫苗10μg／次，采用0、1、6月方案。结果母婴联合免疫阻断治疗后，婴儿免疫成功率91％。结论母婴联合免疫阻断疗法可使HBsAg的滴度下降，减少和阻断HBsAg进入胎儿体内，有效阻断乙肝病毒的母婴垂直传播。

Objective To discuss the clinical meaning of surgical interruption of hepatitis B virus matemal-neonatal vertical transmission. Methods Pregnant woman who is diagnosed to be antigemc positive on the surface of hepatitis B is injected with 200IU hepatitis B immunoglobulm in three prenatal months, once a month, totally three times. After the newborn is born, immediately injected 200IU hepatitis B immu-noglobulin, 15 days later once again. Meanwhile, with the combined application of hepatitis B vaccine, vaccinate hepatitis B vaccine one time 10 μg, adopting the plan of 0, 1st, 6th month. Results After surgical interruption of maternal -neonatal combined immunity, the immune successful rate of the newbore were 91%. Conclusion The surgical interruption of matemal-neonatal combined immunity can make the titer of HBsAg fall, decrease and block the invasion of HBsAg into the body of the newborn, interruption of hepatitis B virus matemal- neonatal vertical transmission efficiently.