一种新型潜在骨固定聚合物的合成与弯曲强度(英文)

Synthesis and flexural strength of a new-type potential bone fixation polymer

目的:通过熔融缩聚法合成一种新型的不饱和聚酯酰胺(即顺酐、苯酐、丙二醇、新戊二醇、己二胺共聚物)并对其进行表征。方法:为用作可降解骨内固定高分子材料,加入一定量的交联剂及引发-促进剂室温预交联后热处理深度交联,观察热处理条件对交联后的不饱和聚酯酰胺弯曲强度和在模拟体液介质及 0.1 mol/L 氢氧化钠标准水溶液中降解(水解)性能的影响。结果:提高热处理时间或温度能显著增加热处理后的不饱和聚酯酰胺的弯曲强度,热处理后的不饱和聚酯酰胺(含有 50%交联剂)弯曲强度最大可以达到 123 MPa。在 195 ℃热处理 18 h 后的不饱和聚酯酰胺(含有 50%交联剂)在模拟体液介质中降解 3 个月后弯曲强度可以保持 114.3 MPa。同时热处理条件和交联剂的含量对控制热处理后的不饱和聚酯酰胺水解率也起重要作用,在整个水解过程中,试样表现整体溶蚀行为。结论:实验合成的新型不饱和聚酯酰胺具有骨内固定材料的潜在优势。

AIM： A new type of unsaturated poly （ester-amide） viz maleic anhydride-phthalic anhydride-propylene glycol-neopentylene glycol-hexane diamine copolymer was prepared by melt polycondensation and characterized. METHODS： To use it as biodegradable bone fixation polymer materials, the flexural strength of unsaturated poly （ester-amide） prepared under different heat treatment conditions was measured after depth cross-linking. The degradation and hydrolysis of the polymer were investigated in phosphate buffer （0.1 mol/L, pH7.4） at 37℃ and in 0.1 mol/L NaOH standard solution at room temperature. RESULTS： The results obtained indicate that increasing heat treatment time or temperature can dramatically increase the flexural strength of cross-linked unsaturated poly （ester-amide）. The maximum flexural strength of the cross-linked polymer containing 50 wt% of cross-linker was 123 MPa. After degradation 3 months, the flexural strength of the cross-linked polymer that contained 50 wt% of cross-linker and was heated at 195℃ for 18 hours could maintain as high as 114.3 MPa. Heat treatment conditions and cross-linker content play an important role to control the mass loss of the cross-linked polymer during the hydrolysis. The polymer exhibits bulk erosion property. CONCLUSION： The preliminary results obtained suggested that the copolymer might be used as bone internal fixation material.