生物电阻抗技术分析人体脂肪成分与心血管病危险因素的相关性

Relationship between body fat composition and cardiovascular disease risk factors: Bioelectrical impedance analysis

目的:利用生物电阻抗技术探讨人体脂成分与多项心血管病危险因素之间的相互关系,为心血管疾病的预防提供理论依据。方法:纳入2005-01/06在解放军总医院健康体检中心进行体检的符合入选条件者856名,其中男601例,女255例,平均年龄(45.2±8.7)岁。采用生物电阻抗技术分析受试者的人体成分组成,主要参数指标包括体脂肪量、去脂肪量、体脂肪率等,同时测定血糖、血脂、血液流变学等生化指标并计算体质量指数和腰/臀围比,对测定结果进行相关分析。结果:①人体去脂肪量与血液生化和血液流变学指标显著相关,而且这种相关程度远远高于体脂肪量、体质量指数及腰/臀围比与上述指标的相关性。②体脂肪率升高者的空腹血糖、三酰甘油、总胆固醇及低密度脂蛋白胆固醇高于体脂肪率正常者(P<0.05),高密度脂蛋白胆固醇低于体脂肪率正常者(P<0.05),此外,体脂肪率升高者的国际标准化比率低于体脂肪率正常者,纤维蛋白原水平高于体脂肪率正常者(P<0.05);以上变化还体现在腰/臀围比正常与腰/臀围比升高人群之间;但是,体质量指数的正常和体质量指数升高人群之间则无此变化。结论:①体脂肪率与心血管风险因子相关,且相关程度高于体质量指数和腰臀围比。②与体质量指数和腰臀围比,体脂肪量、体脂肪率等人体成分测量指标在判定机体是否肥胖和评估血液流变学及血液凝集功能方面更加灵敏。

AIM： To study the correlation of body fat composition with various cardiovascular disease risk factors, and provide theoretical evidences for the prevention of cardiovascular diseases. METHODS： A total of 856 subjects were enrolled by the Physical Examination Center of Chinese PLA General Hospital between January and June in 2005. They included 601 males and 255 females, with a mean age of （45.2±8.7） years. Their body compositions, such as body fat mass （BFM）, fat-free body mass and body fat percentage （BFP）, were measured by bioelectrical impedance analysis Their blood glucose, blood fat, and hemodynamics, as well as other biochemical parameters, were measured by routine procedures. In addition, body mass index （BMI） and waist-to-hip circumstance ratio （WHR） were also calculated. The correlation of body compositions with blood biochemical and hemodynamic indicators was analyzed. RESULTS： （1）Fat-free body loss was strongly correlated with blood biochemical and hemodynarnic indicators, and the correlation was more significant than that with BFM, BMI and WHR.（2）Subjects with higher BFP had higher levels of the fasting blood glucose, total cholesterol, triglycerides and low-density lipoprotein cholesterol, but lower levels of bow-density lipoprotein cholesterol compared with subjects with normal BFP （P 〈 0.05）. Furthermore, the international normalized ratio was lower （P 〈 0.05）, while fibrinogen level was higher in subjects with higher BFP than in subjects with normal BFP （P 〈 0.05）. These significant variances were also observed between groups with higher and normal WHR but not with different BMI. CONCLUSION： （1）BFP is more strongly correlated to cardiovascular disease risk factors than BMI and WHR.（2）Body composition measurements, such as BFM and BFP instead of BMI and WHR, appear to more sensitivities for the estimation of fatness and the evaluation of hemodynamics and blood coagulation function.