毒菌净对实验动物的急性及亚慢性毒性研究

Studies on Acute and Subchronic Toxicities of Dujunjing in Experimental Animals

应用毒菌净对实验动物的急性及亚慢性毒性研究，按寇氏法测得昆明种小白鼠灌服毒菌净的LD50为32025．8mg／kg，95％可信限为30421．1～37916．2mg／kg．亚慢性毒性试验以每天分别用640．5，3202．66405．2mg／kg体重的剂量加入饲料中，供大白鼠自由采食，分别于50d、120d检查动物，包括全身状态、称量体重、血液检验、肝、肾功能检验和病理剖检与组织切片观察等项．结果表明，对大白鼠的生理活动、组织器官无不良影响，并有促进体重增加和速效生血作用，证明毒菌净无毒性，与急性毒性试验所得的结果相符．

The acute and subchronic toxicities of dujunjing by oral administration were stUdied in experimental animals. The acute oral administration LD5o was 32025.8mg/kg,determined by method in Kunming strain small white mouse. The 95% confidence limit was 30421.1~ 37916.2mgthg. The subchronic toxicity was carried ont by mix feed at different dOses 640.5, 3202.6. 6405.2mg/kg day in rats- The rats were examined for state of body,weight,whole blood,liver function,kidney function and histopathology at 50、120 days,after oral administration. The results showed that dujunjing has no effect on organs and physiological action,but it can recrease weight and speed up the produce of blood,there was toxicity,it was consistent with acute toxicity experiment.