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负激活脑区相互作用的任务相关性 被引量:4

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摘要 负激活是脑功能成像中非常普遍的现象,由于其生理机制未知,直到近来才成为系统研究的焦点.目前对负激活的研究主要着重于确定脑血流出现减低的区域,对于执行认知任务过程中,这些脑区之间相互作用及协同工作的模式的研究相对较少.本研究采用基于内部条件的脑区间协方差分析方法(within-condition inter-regional covari-ance analysis,WICA)分析了符号方向判别和数字大小比较两个不同认知任务的负激活情况.结果表明,虽然两个不同任务情况下出现负激活的脑区都集中在后扣带回、楔前叶、角回及额叶区域,但各负激活脑区间的相互作用及活动规律却存在着差异,初步推测可能与外在任务的不同或者与认知负荷或注意资源需求不同有关,精确界定是哪种原因所致还需要进一步的深入研究.
出处 《科学通报》 CAS CSCD 北大核心 2008年第7期788-792,共5页 Chinese Science Bulletin
基金 国家自然科学基金(批准号:60472017,30670699) 教育部新世纪优秀人才支持计划(批准号:NCET-06-0277) 教育部博士点基金(批准号:021010)资助项目
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参考文献24

  • 1Shulman G L, Corbetta M, Buckner R L, et al. Common blood flow changes across visual tasks:Ⅰ . Increasesin subcortical structures and cerebellum, but not in non-visual cortex. J Cogn Neurosci, 1997, 9(5-): 624-647
  • 2Shulman G L, Fiez J A, Corbetta M, et al. Common blood flow changes across visual tasks: Ⅱ. Decreases in cerebral cortex. J Cogn Neurosci, 1997, 9(5): 648-663
  • 3Binder J R, Frost J A, Hammeke T A, et al. Conceptual processing during the conscious resting state: A functional MRI study. J Cogn Neurosci, 1999, 11(1): 80-93
  • 4Mazoyer B, Zago L, Mellet E, et al. Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull, 2001, 54(3): 287-298
  • 5McKieman K A, Kaufman J N, Kucera-Thompson J, et al. A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. J Cogn Neurosci, 2003, 15(3): 394-408
  • 6Raichle M E, MacLeod A M, Snyder A Z, et al. A default mode of brain function. Proc Natl Acad Sci USA, 2001, 98(2): 676-682
  • 7Greicius M D, Krasnow B, Reiss A L, et al. Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proc Natl Acad Sci USA. 2003, 100(1): 253-258
  • 8Fransson P. Spontaneous low-frequency BOLD signal fluctuations: An fMR/investigation of the resting-state default mode of brain function hypothesis. Hum Brain Mapp, 2005, 26(1): 15-29
  • 9Fransson P. How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations. Neuropsychologia, 2006; 44(14): 2836-2845
  • 10Liu Y j, Gao J H, Liott Met al. Temporal dissociation of parallel processing in the human subcortical outputs. Natrue, 1999, 400:364-367

二级参考文献24

  • 1李心天.中国人的左右利手分布[J].心理学报,1983,15(3):268-276. 被引量:196
  • 2刘登堂,江开达,吴彦,刘含秋,姚征宇,徐一峰.精神分裂症首次发病患者词语流畅性作业的功能磁共振成像研究[J].中华精神科杂志,2005,38(3):138-141. 被引量:10
  • 3赵小虎,王培军,唐孝威.静息状态脑活动及其脑功能成像[J].自然科学进展,2005,15(10):1160-1166. 被引量:19
  • 4Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K.Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI[J].中国生物学文摘,2006,20(10):1-1. 被引量:84
  • 5Hutchinson M, Schlffer W, Joseffer S, et al. Task-speclfic deactivation patterns in functional magnetic resonance imaging.Magnetic Resonance Imaging, 1999, 17(10): 1427--1436.
  • 6Rauch SL, Whalen PJ, Curran T, et al. Thalamic deactivation during early implicit sequence learning: A functional MRI study.Brain Imaging, 1998, 9(5) : 865--870.
  • 7Stark CE, Squire LR. When zero is not zero: The problem of ambiguous baseline conditions in fMRI. Proc Nathl Acad Sci,2001, 98(22): 1--6.
  • 8Uludag K, Dubowitz DJ, Yoder EJ, et al. Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI. NeuroImage, 2004,23(1): 148--155.
  • 9Shulman GL, Fiez JA, Corbetta M, et al. Common blood flow changes across visual tasks: I. Increases in subcortical structures and cerebellum, but not in non-visual cortex. J Cogn Neurosci,1997, (9): 624--647.
  • 10Shulman G, Fiez JA, Corbetta M, et al. Common blood flow changes across visual tasks: II. Decreases in cerebral cortex. J Cogn Neurosci, 1997, (9): 648--663.

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