摘要
目的探讨乌司他丁对大鼠胰腺缺血再灌注损伤的保护作用。方法SD大鼠72只随机分为假手术组、缺血再灌注组和乌司他丁组。分别检测胰腺缺血再灌注0h、6h、12h及24h血清中肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)的变化。结果缺血再灌注组的各时点上TNF-α含量明显高于假手术组和乌司他丁组(P<0.05);缺血再灌注组和乌司他丁组在6h、12h、24h的IL-1β含量较假手术组明显增加(P<0.05),但乌司他丁组增高水平明显低于缺血再灌注组(P<0.05)。结论乌司他丁可以抑制大鼠胰腺缺血再灌注损伤所致的急性炎性反应,对大鼠胰腺缺血再灌注损伤有保护作用。
Objective To study the effect of ulinastatin during ischemia-repetfusion injury of rat pancreas. Mothods 72 SD rats were randomly divided into pseudoperation group,ischima-reperfusion group and ulinastatin group. Serum TNF-α and IL-1β were determined during the pancreas ischemia and reperfusion in 0,6,12 and 24 hour respectively. Resulta The expression level of TNF-α and IL-1β in ischemia-reperfusion group were obviously higher than pseudoperation group and ulinastatin group（P〈 0.05 ）. Conelmsion Ulinastatin can suppress the inflammatory reaction during the pancreas ischemia and reperfusion and has protective effects on rat pancreas ischemia-reperfu- sion injury.
出处
《中国现代医生》
2008年第11期30-32,共3页
China Modern Doctor
