摘要
目的探讨大蒜素对食管癌细胞凋亡影响。方法32例食管癌病例随机分为对照组、大蒜素组,并选取正常人作为正常组共3组。入院后给予大蒜素给60mg/d静滴,日一次,连用7d,直至手术,无其他化疗措施。留取肠组织标本以4%多聚甲醛固定,石蜡包埋,4μm连续切片,HE染色,光镜下观察,并行TUNEL染色了解各组的细胞凋亡情况。结果与对照组相比,大蒜素组中的细胞凋亡数量明显增加(P<0.01)。结论大蒜素可通过增加细胞凋亡而抑制肿瘤细胞的发生、发展。
Objective To explore effects of allicin on apoptosis in patients with esophageal carcinoma. Methods 32 patients with carcinoma of rectum were adrandomly divided into 2 equal groups with each 16 patients in blank control and allicin group, and 12 healthy people. Allicin group was administration of allitridi （60mg/d） for 7 days dose-dependently. Apoptosis of cells was detected with TUNEL. Macroscopic changes in the intestinal tract were also kept under observation. Results As compared with changes in blank control, apoptosis of carcinoma of rectum was increased （P〈 0.01 ）. Conclusion Allicin is shown to exert a protective effect on the carcinoma of rectum.
出处
《中国现代医生》
2008年第12期37-38,共2页
China Modern Doctor
关键词
大蒜素:食管癌
细胞凋亡
实验
对比
Allicin
Esophageal carcinoma
Apoptosis
Experiment
Contrast
