1Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med, 2002, 346(6) :393.
3Johansen K. Efficacy of metformin in the treatment of NID-DM, Diabetes Care, 1999,22:33.
4Tiikkainen M, Ha kkinen AM, Korsheninnikova E, et al. Effects of rosiglitazone and mefformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes ,2004,53:2169.
5UKPDS Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes. Lancet ,1998, 352:854.
2Pan CY, Lu JM, Tian H, et al. Study of the prevalence of diabetes mellitus in adults in the Shougang Corporation in Beijing.Diabet Med, 1996, 13:663-668.
3The Diabetes Prevention Program Research Group. The Diabetes Prevention Program. Diabetes Care, 1999, 22 : 623-634.
4Li CL, Pan CY, Lu JM, et al. Effect of metformin on patients with impaired glucose tolerance. Diabet Med, 1999, 16: 477-481.
6Iannello S,Camuto M,Cavaleri A,et al.Effects of short -term metformin treatment on insulin sensitivity of blood glucose and free fatty acids[].Diabetes Obesity and Metabolism.2004
7Gulliford M,Latinovic R.Mortality in type 2 diabetic subjects prescribed metformin and sulphonylurea drugs in combination:cohort study[].Diabetes Metabolism Reviews.2004
8Khan JK,Pallaki M,Tolbert SR,et al.Lactic acidemia associated with metformin[].Annals of Pharmacotherapy.2003
9Hokanson JE,Austin MA.Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level : a meta-analysis of population-based prospective studies[].Journal of Cardiovascular Risk.1996
10DeFrozo RA,Goodman AM.Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus[].The New England Journal of Medicine.1995
