中性粒细胞碱性磷酸酶活性测定对系统性红斑狼疮的诊断价值

The diagnostic value of neutrophilic alkaline phosphatase activity detection in systemic lupus erythematosus

目的探讨中性粒细胞碱性磷酸酶在系统性红斑狼疮诊断中的价值。方法采用AS-BI法对30例初诊的SLE患者（SLE组）及30例体检健康女性（对照组）外周血涂片进行NAP染色，观察NAP阳性率及阳性积分。结果SLE患者阳性率、阳性积分分别为（22.1±8．8）％、（22．2±8.9）分；健康对照组阳性率、阳性积分分别为（56．8±9．4）％、（58．2±9．8）分，两者比较差异有统计学意义（P〈0．01）。结论NAP检测对初诊的SLE患者有一定的诊断价值；其在SLE中活性降低的机制尚待进一步探讨。

Objective To explore the diagnostic value of NAP activity detection in SLE. Methods Tech- nique of AS-BI was used to NAP staining of peripheral blood smear in patients with newly-diagnosed SLE（30 cases） and normal healthy women（30 cases） ,to observe positive rate and positive score of NAP. Results The positive rate was （22.1±8.8） % in group SLE, （56.8±9.4） % in group normal; The positive score was （22.2±8.9） in group SLE, （58.2±9.8） in group normal. The positive rate and positive score were much lower in patients with SLE comparing with those in group normal. Differences were statistically significant（P〈 0.01 ）. Conclusions The detection of NAP is useful in the patients with newly-diagnosed SLE, but we must go on researching the pathogenesis of NAP activity decreased in SLE.