SPECT追踪观察短暂性脑缺血发作患者巴曲酶干预治疗的临床研究

The clinical research of Batroxobin intervening treatment using SPECT to tracing observe patients with transient ischemic attack

目的探讨SPECT追踪观察短暂性脑缺血发作患者巴曲酶干预治疗的临床意义。明确短暂性脑缺血发作患者干预治疗的重要性。方法37例头部CT或MRI均正常的短暂性脑缺血发作患者,采用SPECT扫描技术,追踪观察治疗前和治疗后局部脑血流灌注情况比较;同时观察巴曲酶治疗组与非巴曲酶治疗组采用不同治疗方法的临床疗效。结果SPECT脑血流灌注显像显示治疗后在脑血流灌注得改善上显著好于治疗前。巴曲酶治疗组治疗结果明显好于非巴曲酶治疗组(P<0.05),降低了脑梗死的发生率。结论SPECT追踪观察治疗前后对比可作为疗效评价的一个客观指标。短暂性脑缺血发作的巴曲酶的干预治疗,对于防止脑梗死的发生或延缓脑梗死的发生具有临床意义,可以减少脑梗死的发病率及致残率。

Objective To discuss the clinical meaning of Batroxobin intervening treatment using SPECT to tracing observe patients with transient ischemic attack. Define the importance of intervening treatment to patients with transient cerebral ischemic attack. Methods Compare the partial cerebral blood perfusion of 37 patients with normal head CT or MRI and transient ischemic attacked before and after the treatment, at the same time observe the clinical curative effect of different treatment adopted by Batroxobin group and non- Batroxobin group. Results The improvement of the cerebral blood perfusion was profoundly than before which was displayed by the SPECT cerebral blood perfusion imaging after the treatment. The curative effect of the Batroxobin group was better than that of non- Batroxobin group （P 〈 0.05）, reducing the attack rate of cerebral infarct. Conclusions The SPECT tracing observation before and after the treatment can be used as a objective guideline for evaluating the curative effect. The Batroxobin intervening treatment of transient ischemic attack can reduce the attack or disabling rate of cerebral infarct, which has clinical meaning of preventing or retarding the attack of cerebral infarct.