溶血磷脂酸和超敏C反应蛋白与缺血性脑血管病的关系

The relationship between lysophosphatidic acid and high sensitive C-reactive protein and Ischemic cerebrovascular disease

目的探讨血浆中溶血磷脂酸(LPA)、超敏C-反应蛋白(Hs-CRP)的水平与缺血性脑血管病的关系。方法检测45例急性脑梗死患者、28例短暂性脑缺血发作患者血浆溶血磷脂酸和超敏C-反应蛋白浓度,并与46例健康体检者(正常对照组)比较。结果短暂性脑缺血发作组和急性脑梗死组血浆LPA含量分别为(9.31±3.12)μmol/L、(8.25±2.94)μmol/L均显著高于对照组(2.56±1.40)μmol/L,P<0.01。短暂性脑缺血发作组和急性脑梗死组血浆Hs-CRP含量分别为(10.58±3.45)mg/L、(12.36±3.74)mg/L均显著高于对照组(2.25±2.00)mg/L,P<0.01。结论溶血磷脂酸和超敏C-反应蛋白可能是缺血性脑血管病的独立危险因素之一,为缺血性心脑血管病的早期干预和防治提供了新的靶点。

Objective To explore the relation level of plasma lysophosphatidic acid（LPA）,high sensitive C-reactive protein（Hs-CRP） and ischemic cerebrovascular disease. Methods The plasma levels of LPA and Hs-CRP were measured in 45 patients with Acute cerebral infarct（ACI）,28 patients with Transient ischemic attack（TIA） ,and compared with 46 healthy control. Results The level of LPA in the TIA and ACI group [ （ 9. 31± 3.12 ）μmol/L, （ 8.25 ± 2.94 ） umol/L] were significantly higher than that in the control group （2.56±1.40）μmol/L （P 〈 0.01）. The level of Hs-CRP in the TIA and ACI group[（10. 58±3. 45） ,（12.36±3.74）] were significantly higher than that in the control group（2.25± 2.00） mg/L （P〈0.01）. Conclusions LPA and Hs-CRP may be a risk factor for ischemic cerebrovascular disease, provided the new targets for the early intervention and treatment of ischemic cerebrovascular diseases.