唐山市健康人群流脑带菌实验室监测

Survey of N meningitidis carrier in healthy confluence of Tangshan

目的：了解唐山市健康人群流行性脑脊髓膜炎（简称流脑）的带菌率、带菌群型及菌株药物敏感性情况，为预防和控制流脑的暴发流行提供依据。方法：依据河北省卫生防疫站1998年版《标准技术操作规程》中脑膜炎奈瑟氏菌检验方法和抗生素药物敏感试验判定标准进行。结果．2001～2007年共分离到流脑菌60株，其中A群10株，占16．67％，B群27株，占45％，C群2株，占3．33％，其它群21株，占35％，2006年在健康人群中首次分离到C群；选取20株流脑菌进行药物敏感试验，发现其对头孢拉定、菌必治、环丙沙星耐药率较低，为25％～30％。结论：通过不同年份健康人群流脑带菌实验室监测结果分析，对掌握唐山市流脑菌群分布特征和变迁趋势及菌株药物敏感性具有重要意义。

Objective：To know the carriers, moldes, medicament sensitivities of epidemic cerebrospinal meningitis in healthy confluence in Tangshan to supply gist with prevent and control the outbreak of the epidemic cerebrospinal meningitis. Methods： According to the test menthod of N meningitidis and the standard of antibiotic medicament sensitivity in the standard technology operate criterion（1998） of Hebei CDC. Results： Sixty epidemic cerebrospinal meningitis bacteria were separated from 2001 to 2007 ,the type A ： 10 strains （ 16.67% ）, the type B ： 27 strains （ 45% ） , the type C ： 2 strains （ 3.33 % ）, the others ： 21 strains （35%） ,it is the first time that the type C were separated from the health peple in 2006. Choose 20 strains bacteria to prosecute medicament sensitivity test ,the result is that the rate of drug tolerance of Cefotaxime, Ceftriaxone sodium, Ciprofloxacin are low （25% -30% ）. Conclusion：Acoording to the test of the bacteria carrier in health confluence, it would play a important role in control of distribution characteristic and vicissitude trend and medicament sensitivity of the N meningitidis.