^(99m)Tc-ECD脑显像定量分析对小儿原发性癫痫病灶定位诊断的研究

Study on Location Diagnosis by Quantitative Analysis Brain Imaging with 99mTc-ECD in Paediatric Patient with Primary Epilepsia

目的：采用相对定量分析法评估９９ｍＴｃ－ＥＣＤ脑血流灌注显像对小儿原发性癫痫定性和病灶定位的诊断价值。方法：２１例ＣＴ检查正常的小儿原发性癫痫病人进行９９ｍＴｃ－ＥＣＤ脑显像和相对定量分析，并同步进行ＥＥＧ检查。结果：２１例病人ＳＰＥＣＴ显像１８例异常，３例正常，阳性率８５７％，假阴性１０％，１８例脑显像异常患儿中，１６例局部脑血流（ｒＣＢＦ）减少，９９ｍＴｃ－ＥＣＤ摄取率７２６±８９％，２例在额叶有限局性ｒＣＢＦ增加，９９ｍＴｃ－ＥＣＤ摄取率分别为１４９５％和１３０９％。ＥＥＧ检查２１例病人２０例异常，１例正常，阳性率９５２％，能定位诊断的７例，定位率为３５％。结论：９９ｍＴｃ－ＥＣＤ脑显像相对定量分析法对小儿原发性癫痫病灶的定位有临床意义，优于ＥＥＧ。

PURPOSE:Value of qualitative and location was assessed by relative quantitative analysis99mTc-ECD brain imaging in children with primary epilepsia. METHOD:99mTc-ECD brain imaging was performed on 21 cases in children with primary epilepsia and normal CT. Their electroencephalogram was synchronous recored. RESULT:18 cases of 21 patients had abnormalities on SPECT imaging,3 cases were normal imaging. positive rate was 857%and false negative 10%. 16 cases of 18 abnormalities showed decreased regional cerebral blood flow(rCBF) and99mTc-ECD uptake rate was 726±87%, 2 cases increased rCBF in frontal lobe and99mTc-ECD uptake rate was 1495% and 1309%, respectivly. 20cases of 21 patients had epileptic wave on EEG,1 case was normal, and positive rate was 95.2%. 7 cases were located by EEG, location rate was 35%. CONCLUSLON:99mTc-ECD brain imaging quantitative analysis appear to be useful in location of focus,and had an advantage over EEG.