非酒精性脂肪性肝病的自然史和危险因素

The natural history and risk factors of non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是一种肝组织病理学改变,与酒精性肝病相类似,但无过量饮酒史的临床病理综合征。现有的研究提示大多数NAFLD是一个良性病变,但一些患者仍可导致肝硬化、肝癌和肝功能衰竭。肥胖、胰岛素抵抗、C-反应蛋白及糖尿病、高血脂、高血压、HCV等在NAFLD的发病过程中都是重要的危险因素,因此预防和治疗相关的危险因素对于NAFLD的发生和发展至关重要。

Non-alcoholic fatty liver disease （NAFLD） is a pathological change of liver tissue which resembles to that of alcoholic fatty liver disease, but it is a clinicopathological syndrome without alcohol consumption. It is well accepted that the majority patients of non-alcoholic fatty liver disease have a benign course, but it also develops to cirrhosis, hepatic carcinoma and liver failure in some cases. Risk factors such as obesity,insulin resistance, C-reactive protein, diabetes mellitus, hyperlipidemia, hypertension and HCV infection are all play an important role on NAFLD. With the occurrence and development of NAFLD, it is essential to prevent and treat these risk factors.