Th1/Th2及CD_4^+CD_(25)^+调节性T细胞与非酒精性脂肪性肝炎

Th1/Th2 and CD_4^+ CD_(25)^+ regulatory T-cells in non-alcoholic steatohepatitis

非酒精性脂肪性肝炎(NASH)是与代谢性疾病相关的一类疾病,目前其发病机制仍未完全清楚。CD4+T辅助细胞具有重要的免疫功能,优先向Th1亚群分化参与NASH的发病,Th1/Th2比值下降,促炎症细胞因子IFN-γ、TNF-α分泌增多,机制可能与胰岛素抵抗或者肝内免疫功能异常有关。CD4+CD25+调节性T细胞分泌TGF-β、IL-10抑制性细胞因子,通过抑制Th1和Th2的增殖和分化,控制疾病的进程。此文主要就Th1/Th2及CD4+CD25+调节性T细胞在非酒精性脂肪性肝炎中的研究进展作一综述。

Non-alcoholic steatohepatitis（NASH） appears to be associated with metabolic syndrome. CD4^＋ T helper cells have an important immune function and toward a Thl phenotype in NASH, Th1/Th2 ratio decreases, with increased proin-flammatory eytokines IFN-γ and TNF-α production. The mechanism may be related to insulin resistance or innate immune function alteration. CD4^＋ CD25^＋ regulatory T cells secrete TGF-β and IL-10 inhibitory eytokine, control the disease process through inhibiting Th1/Th2 cells proliferation and differentiation.