摘要
趋化因子是控制细胞定向迁移的细胞因子,其功能由趋化因子受体介导。在溃疡性结肠炎中,许多趋化因子及部分受体表达增加,并在发病机制上起重要作用。针对趋化因子及其受体的靶向治疗能减轻炎症损伤,有望成为一种新的溃疡性结肠炎治疗方法。
Chemokines are chemotactic cytokines that can direct cells trafficking, conducting their functions via chemokine receptors. Many chemokines and partly their receptors show increased expression in ulcerative colitis, which play an important role in the pathogenesis of the disease.. Targeted therapy that aims directly at chemokines and their receptors can ameliorate inflammatory damage, and can be a novel therapeutics for ulcerative colitis.
出处
《国际消化病杂志》
CAS
2008年第2期139-141,共3页
International Journal of Digestive Diseases