肠道通透性研究进展

Progress in intestinal permeability

肠道通透性异常的现象在很多人类疾病中都存在,特别是在一些自身免疫性疾病中,肠道通透性的增加被认为与疾病的发病机制相关。因此,目前肠道通透性改变和疾病发病的关系受到关注。此文从肠道上皮屏障的结构、肠道通透性的检测方法及当前临床疾病相关的研究现状进行阐述。

There are a variety of human diseases in which it has been suggested that abnormal permeability is important. Especially, in several autoimmune conditions it appears that in some conditions increased permeability is critical to the development of disease. In present, it has been paid close attention to the relations that between the changes of intestinal permeability and the development of disease. The goal of this review is to describe the structure of epithelial barrier function, methods to evaluate intestinal permeability, and most importantly the relevance of abnormal permeability to clinical disease.