肝炎后肝硬化患者血清瘦素水平的变化与胰岛素抵抗关系的研究

The study of serum leptin level in patients with post hepatitis liver cirrhosis and relationships with insulin resistance

目的:探讨肝硬化与瘦素的相关性、不同肝功能状态下瘦素的表现规律以及与胰岛素抵抗的关系。方法:选择肝炎后肝硬化患者97例,按肝功能分A、B、C3级,各级分别为34、32和31例,对照组30例,分别测定体重指数(BMI)、血脂、血糖、空腹胰岛素、瘦素和肝硬化指标,计算稳态模型胰岛素抵抗指数(HOMA-IR)并进行对比分析。结果:乙肝后肝硬化瘦素水平不仅与对照组比较有极显著性差异(P<0.01),而且即使控制了BMI与性别后仍随肝功能A、B、C的分级进行性升高,女性比男性的水平高,HOMA-IR与瘦素显著相关。结论:乙肝后肝硬化瘦素水平比对照组显著性增高,而且与肝功能异常的严重程度及胰岛素抵抗有关。

Objective：To investgate the serum leptin in patients correlation with post-hepatitis B cirrhosis and relationship with its disciplinarian behavior in different liver function and insulin resistance. Methods：97 patients with posthepatitis B cirrhosis were divided A,B,C groups according to Child-Pugh classification （liver function）,34 patients of A groups, 32 B,31 C and 30 normal controls,and observed body mass index （BMI）,dyslipidemia, fasting blood sugar （FBS） ,fasting serum insulin （FINS） ,leptin and index of liver cirrhosis,and HOMA-insulin resistance index （HOMAIR） was caculated,and all index were analysed and compared with each group and control. Results ：The serum leptin level of post-hepatitis B cirrhosis was not only significantly higher than that of controls,but also leptin A,B,C increased in procession even after control BMI and sex. The females were higher that of males. HOMA-IR was correlated with level of leptin. Conclusions：Serum leptin levels in post-hepatitis B cirrhosis patients are significantly increased with normal controls, and correlated with the severity of liver dysfunction and insulin resistance.