摘要
目的探讨不同类型高脂肪酸饮食对大鼠肝脏过氧化物酶体脂肪酸β-氧化的影响。方法用高不饱和和高饱和脂肪酸饮食饲养大鼠24w,观察体重(BW),血清总胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(FFA),肝脏过氧化氢酶、脂酰CoA氧化酶和过氧化物酶体脂肪酸β-氧化活性的变化及肝脏超微结构的改变。结果各实验组血清BW、TG、TC、FFA较对照组有不同程度升高(P<0.01)。各实验组大鼠肝脏过氧化氢酶、过氧化物酶体脂肪酸β-氧化、脂酰CoA氧化酶活性较对照组明显升高(P<0.05,P<0.01)。24w后高脂饮食组大鼠肝细胞内有数量不等的脂滴储积。结论高不饱和脂肪酸、高饱和脂肪酸饮食长期摄入可导致大鼠脂质代谢紊乱,肝脏中的过氧化氢酶、脂酰CoA氧化酶和过氧化物酶体脂肪酸β-氧化的活性升高。
Objective To explore the effect of high different type of fatty acid diet on the activity of peroxisome fatty acid β-oxidation in the livers of rats. Methods High saturated fatty acid and high unsatured fatty acid diets had been administratered to different group of rats for 24 weeks respectively. The alterations of body weight (BW) , total cholesterol ( TC ) , triglyceride ( TG), and free fatty acid ( FFA ) in serum and the alterations of the activities of peroxisome fatty acid β-oxidation,catalase and acyl-CoA oxidase in the livers were observed. Results BW,TC,TG, FFA in experimental groups were higher than those in control group in the same period. The activities of peroxisome fatty acid β-oxidation ,catalase and acyl-CoA oxidase in livers of the rats in experimental groups were increased more significantly than those in control group on 24 week. Conclusions Long period high saturated fatty acid and high unsatured fatty acid diets can result in metabolic disorder of lipid and the increasing of activities of peroxisome fatty acid β-oxidation,catalase and acyl-CoA oxidase of liver.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2008年第8期742-744,共3页
Chinese Journal of Gerontology
基金
河北省自然基金资助项目(编号303552)