期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基因敲除鼠在动脉粥样硬化研究中的应用 被引量：10

Application of gene-knocking out mice in the research of atherosclerosis
下载PDF
导出
摘要 ApoE和LDL-R基因敲除鼠可自发形成动脉粥样硬化斑块,是动脉粥样硬化研究的常用模型。在此基础上应用基因打靶技术建立的白介素-1、C反应蛋白、清道夫受体、IgGFc、补体C1q及CD44等模型对研究动脉粥样硬化中炎症和免疫因子的作用机制起了重要作用。 ApoE and LDL-R knocking out mouse may spontaneously develope atherosclerosis and so is applied in the research of atherosclerosis. These mouse model, the model generated by gene targeting, like IL-1, C-reactive protein, scavenger receptor, IgG Fc, C 1 q and CD44, play important role in research of inflammatory factor and immune factor on atherosclerosis.
作者 谢谨捷 杨娅
机构地区 首都医科大学北京安贞医院超声影像科
出处 《基础医学与临床》 CSCD 北大核心 2008年第4期400-402,共3页 Basic and Clinical Medicine
基金 国家自然科学基金(30470722)
关键词 基因敲除小鼠 动脉粥样硬化 心血管疾病 knock out mice atheroselerosis cardiovascular disease
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献12

  • 1Plump AS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells[ J ]. Cell, 1992,71:343 - 353.
  • 2Zhang Sunny H, Reddick RL, Piedrahita JA, et al. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E [ J ]. Science, 1992,258 : 468 - 471.
  • 3康爱君,田枫,张阔,周淑佩,郑振辉.载脂蛋白E基因缺陷(C57BL/6J-ApoE)小鼠血脂及病理组织学观察[J].中国比较医学杂志,2006,16(2):85-88. 被引量：12
  • 4刘剑刚,董国菊,史大卓,王永炎.载脂蛋白E基因敲除小鼠不同周龄动脉粥样硬化的病理变化[J].中国动脉硬化杂志,2005,13(6):689-692. 被引量：23
  • 5Ishibashi S, Herz J, Maeda N, et al. The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins [ J ]. Proc Natl Acad Sci USA, 1994,91:4431 - 4435.
  • 6Merhi-Soussi F, Kwak BR, Magne D,et al. Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice [ J ]. Cardiovasc Res ,2005,66:583 - 593.
  • 7Zhao Zhenze, de Beer MC, Cai L, et al. Low-densitylipoprotein from apolipoprotein E-deficient mice induces macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent manner [ J ]. Atheroscler Thromb Vasc Biol,2005,25 : 168 - 173.
  • 8Paul A, Ko KW, Li L, et al. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice[ J]. Circulation,2004,109:647 - 655.
  • 9Hernandez-Vargas P, Ortiz-Munoz G, Lopez-Franco O, et al. Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice [ J ]. Circ Res ,2006,99 : 1188 - 1196.
  • 10Bhatia VK,Yun S, Leung V, et al. Complement Clq reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice[ J]. Am J Pathol,2007,170:416 - 426.

二级参考文献21

  • 1张春妮,汪俊军,庄一义,刘小传,强宏娟,陈大宁.脂蛋白对巨噬细胞的作用研究进展[J].中国动脉硬化杂志,2005,13(2):225-227. 被引量：3
  • 2范乐明.动脉粥样硬化炎症机制的再认识[J].中国动脉硬化杂志,2005,13(3):249-253. 被引量：73
  • 3PlumpAS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES Cells [J]. Cell, 1992,71(10): 343-353.
  • 4Breslow JB. Mouse models of atherosclerosis[J]. Science, 1996,272:685-688.
  • 5Zhang SH, Reddick RL, Piedrahita JA, et al, Spontaneous hypercholesterolemia and arterial lesions in mice lacking aopolipoprotein E[J]. Science, 1992,258(10):468-471.
  • 6Zhang SH,Reddick RL,Piedrahita JA,Maeda N.Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoproterin E.Science,1992,258:468-471
  • 7Yutaka N,Andrew SP,Elaine WR.ApoE-Deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.Arteriosclerosis Thrombosis,1994,14 (1):133-140
  • 8Chen J,Tung CH,Umar M,Vasilis N,Robert G,Mark C,et al.In vivo imaging of proteolytic activity in atherosclerosis.Circulation,2002,11 (6):2 766-771
  • 9Libby P. Changing concepts of atherogenesis[ J] . J Intern Med,2000, 247(3) : 349 - 358.
  • 10Constantinides P, Chakravarti RN. Rabbit arterial thrombosis production by systemic procedures[J] . Arch Pathol, 1961, 72:197 - 208.

共引文献61

同被引文献109

引证文献10

二级引证文献52

基础医学与临床
2008年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部