中药蜜炼多补膏抗肿瘤作用的实验研究

Experimental Study on Antineoplastic Effect of Honeyed Tonic Extract

以荷瘤动物模型，观察中药制剂蜜炼多补膏（简称多补膏）对抑瘤、免疫和放化疗减毒的作用。结果表明：蜜炼多补膏中剂量组（３１．８ｇ／ｋｇ）对Ｓ１８０、肝癌抑瘤率分别为３１．８３％、３３．８６％；蜜炼多补膏配伍化疗药ＦＴ－２０７组的抑瘤率为５８．９１％、６３．９５％，均高于单用ＦＴ－２０７组（４６．５６％、４８．２８％），Ｐ＜０．０５；能促进化疗荷瘤小鼠血清抗体（溶血素）的生成作用，光密度（ＯＤ）值为０．３４８±０．０４５，提高Ｔ淋巴细胞百分率（４１．０±６．７）％和碳廓清指数（０．０２９±０．１１），与生理盐水组比较，均有显著性差异（Ｐ＜０．０１）；能显著缓解γ射线及化疗药环磷酰胺所造成的动物机体损伤，使动物体重增加，外周血白细胞回升，ＥＡＣ腹水瘤细胞数明显减少，与γ射线照射组和环磷酰胺组比较有显著性差异（Ｐ＜０．０１）。能延长腹腔注射阿霉素动物的平均寿命（Ｐ＜０．０５）。提示本药有增强与调节免疫功能的作用，有减轻放化疗对骨髓造血功能的抑制，能有效地减轻放化疗的毒副反应，与放化疗结合使用有协同效应，具有一定的抗肿瘤作用。

In this article, the antineoplastic effect of Honeyed Tonic Extract (HTE) on the mice with tumor was observed. The results showed that the tumor-inhibiting rate of HTE on S180 and liver cancer was 31.86 % and 33.68% respectively,and that of HTE with FT-207 was 58.9% and 63.95% which was higher than that of FT-207 alone ( 46.56% and 48.28% ). HTE had effects of improving the production of antibody in serum of the mice with tumor after chemotherapy (OD: 0.348 ± 0.045 ),raising the percentage of T-lymphocyte ( 41.0±6.7%) and the carbon clearance ( 0.29±0011 ),the differences being very significant as compared with normal saline (P< 0.01 ).Meanwhile,HTE can also relief the injury caused by γ_ray and cyclophosphamide, increase animal's weight and the number of peripheral white blood cells and decrease the tumor cell number in EAC ascitic tumor. Compared with the group of γ-ray and cyclophosphamide,the difference was also obvious(P< 0.01 ).These indicated that HTE has the effects of increasing and regulating immunologic function, reducing the inhibition of bone marrow and toxic and side reaction after radiotherapy and exerts a synergetic antineoplastic effect.