^99Tc^m-环丙沙星和^99Tc^m-HIgG炎症兔模型显像的比较

Comparison of biological behavior of ^99Tc^m-ciprofloxacin （Infecton） and ^99Tc^m-HlgG in rabbit models of inflammation

目的通过炎症兔模型^99Tc^m-环丙沙星与^99Tc^m-非特异性人多克隆免疫球蛋白（HIgG）显像的比较，评估^99Tc^m-环丙沙星的特异性。方法建立4组兔模型。组1为无菌性炎症模型，组2为细菌性炎症模型，组3为右后肢无菌性炎症、左后肢细菌性炎症模型，组4为空白对照组。各组饲养7d后行^99Tc^m-环丙沙星显像，2d后再行^99Tc^m-HIgG显像，并比较2次显像结果。结果静脉注射^99Tc^m-环丙沙星1h炎症部位就显影，延迟至3～4h，图像更清晰。组1无菌性炎症兔模型^99Tc^m-环丙沙星显像阴性，^99Tc^m-HIgG阳性。组2细菌性炎症兔模型^99Tc^m-环丙沙星和^99Tc^m-H1gG显像均为阳性。组3^99Tc^m-环丙沙星显像在左后肢细菌性炎症中有异常放射性分布，右后肢非细菌性炎症中未见明显显影；^99Tc^m-HIgG显像在左后肢细菌性炎症和右后肢非细菌性炎症中均有放射性浓聚。组4则2种显像均为阴性。结论^99Tc^m-环丙沙星能特异定位细菌性炎症灶，在非细菌性炎症部位无浓聚。最佳显像时间为给药后3h。

Objective ^99Tc^m-ciprofloxacin （ Infecton ） and^99Tc^m-HIgG are both radiopharmaceuticals for inflammation and infectious disease imaging. It was reported that ^99Tc^m-ciprofloxacin （Infecton） was able to distinguish inflammation from infection, while ^99Tc^m-HIgG was a nonspecific agent. The study was designed to compare the in vivo characteristics between ^99Tc^m-ciprofloxacin （Infecton）and ^99Tc^m-HIgG in rabbit model of inflammation. Methods Eight rabbits were grouped as inflammation model （the first group）, infection model （the second group）, concomitant inflammation and infection model （the third group）, and control （the fourth group） groups. A total of 185 MBq （0.5 ml） ^99Tc^m-ciprofloxacin （Infecton） was administered intravenously to each rabbit, a serious dynamic images were acquired till 24 h post-injection. Repeated examination with ^99Tc^m-HIgG was carried out 2 d later. Results ^99Tc^m-ciprofloxacin （Infecton） scan was negative in the inflammation models and controls, and was positive in the infection models. In the third group ^99Tc^m- ciprofloxacin （Infecton） showed infection focus in the left thigh but negative uptake at inflammation focus in the right thigh. ^99Tc^m-HIgG scan were positive in all models. The optimal image time for ^99Tc^m-ciprofloxacin （Infecton） was 3 h after administration, but positive image could still be observed 24 h later. Conclusion ^99Tc^m-ciprofloxacin （Infecton） appears to specifically accumulate in the infective lesion.