土三七致肝小静脉闭塞病诊断及治疗体会

The Diagnosis and Treatment of Hepatic Veno-Occlusive Disease Induced by Gynura Root

目的探讨肝小静脉闭塞病(hepatic veno-occlusive disease,HVOD)的诊断及治疗效果。方法回顾性分析我院3例土三七致HVOD患者的临床和病理特征。结果所有患者以腹胀、腹水和肝肿大为主要表现。2例患者的组织病理学表现为肝窦扩张、瘀血、肝索挤压、萎缩、肝细胞变性坏死。结论土三七所致肝小静脉闭塞病临床表现无特殊性,肝穿是重要的诊断方法。

Objective To investigate the diagnosis and treatment of hepatic veno-occlusive disease（HVOD）. Methods Clinical and pathologic features of 3 HVOD induced by gynura root were studied retrospectively. Results All the patients presented with abdominal distension, ascites and hepatomegaly. The pathologic manifestations of two patients were hepatic sinus dilation,extrusion and atrophy of cords,hepatocytes necrosis and cholestasis. Conclusion The clinical manifestations of HVOD induced by gynura root have no specificity and its diagnosis should mainly rely on liver biopsy.