摘要
目的研究311nm窄谱中波紫外线(NB-UVB)对寻常性银屑病患者血清和皮损中IFN-γ和IL-4的影响。方法40例寻常性银屑病患者随机分为NB-UVB和对照两组,每组20例,NB-UVB组每周光疗3次,共4周,对照组不予光疗。治疗前后分别以银屑病严重程度PASI评分标准评分,以ELISA法测定血清中IFN-γ和IL-4含量,以免疫组化方法和图像分析系统分析IFN-γ和IL-4在银屑病皮损中的表达,结果以积分光密度值(IOD值)表示。结果两组患者治疗后PASI评分均显著下降(P<0.05),且NB-UVB组低于对照组(P<0.05);血清IFN-γ水平均下降(P<0.05),而IL-4水平无明显变化;皮损中IFN-γ表达明显下降(P<0.05),且NB-UVB组低于对照组(P<0.05);IL-4水平增高(P<0.05),且NB-UVB组高于对照组(P<0.05)。结论NB-UVB可以调节寻常性银屑病血清IFN-γ水平和皮损中IFN-γ,IL-4的表达,改善患者体内Th1,Th2失衡状态达到治疗效果。
Objective To determine the effect of 311 nm narrow band UVB （NB -UVB）on the level of IFN -γ and IL- 4 in serum and lesions of patients with psoriasis vulgaris. Methods 40 patients with psoriasis vulgaris were divided randomly into NB -UVB group and control group, and each group contained 20 patients who received phototherapy 3 times per week, and 4 weeks totally, and control group was not given phototherapy. The severity of psoriasis was evaluated by PASI score, and serumal IFN -γ and IL - 4 were examined by ELISA, and the expression of IFN -γ and IL - 4 in lesions were detected by immunohistochemistry and image - analysis system before and after treatment. Results PASI score decreased significantly after treatment （ P 〈 0.05 ）in both groups, and which in NB -UVB group decreased more significant than that in control group. The level of serumal IFN -γ decreased in both groups and the level of serumal IL -4 had no significant change after treatment（ P 〈0.05 ）. The level of IFN -γ in lesions decreased significantly after treatment（ P 〈 0.05 ） , and which in NB - UVB group decreased more than that in control group（ P 〈 0.05 ）. The level of IL - 4 increased significantly after treatment（ P 〈 0.05 ） , and which in NB - UVB group increased more significantly than that in control group （ P 〈 0.05 ）. Conclusion NB - UVB has a therapeutic effect on psoriasis vulgaffs by regulating the level of IFN -γ in serum and lesions to improve the imbalance of Th1 and Th2.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2008年第4期214-216,228,共4页
The Chinese Journal of Dermatovenereology
