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多发性骨髓瘤患者使用双膦酸盐引起颌骨坏死二例 被引量:3

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摘要 例1,男,63岁。2004年2月因胸痛2个月余,骨穿检查示浆细胞占0.230,IgD2400g/L,24h尿轻链λ34770mg/24h,血肌酐212.3μmol/L,X线检查示双侧肋骨、颅骨、胸腰椎多发性溶骨性改变,确诊多发性骨髓瘤IgDⅢ期B组。确诊后即给予帕米膦酸二钠每次90mg,每月1次,给药2次后减量为每月60mg,直到2005年6月出现左上颌骨坏死后停用。
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第4期278-278,共1页 Chinese Journal of Hematology
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  • 1孙明霞,赵玉亮,林蓉燕,王晓云,金瑢.帕米膦酸二钠治疗骨转移癌致上颌骨坏死一例[J].中国肿瘤临床与康复,2006,13(2). 被引量:3
  • 2Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) inducedavascular necrosis of the jaws: a growing epidemic [J]. J OralMaxillofac Surg, 2003, 61(9): 1115-1117.
  • 3Advisory Task Force on Bisphosphonate -Related Ostenonecrosisof the Jaws, American Association of Oral and MaxillofacialSurgeons. American Association of Oral and MaxillofacialSurgeons position paper on bisphosphonate -related osteonecrosisof the jaws[J]. J Oral Maxillofac Surg, 2007, 65(3): 369-376.
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  • 7Yoneda T, Hagino H, Sugimoto T, et al. Bisphosphonate -relatedosteonecrosis of the jaw: position paper from the Allied TaskForce Committee of Japanese Society for Bone and MineralResearch, Japan Osteoporosis Society, Japanese Society ofPeriodontology, Japanese Society for Oral and MaxillofacialRadiology, and Japanese Society of Oral and MaxillofacialSurgeons[J]. J Bone Miner Metab, 2010,28(4): 365-383.
  • 8Ruggiero SL, Dodson TB, Assael LA, et al. American Associationof Oral and Maxillofacial Surgeons position paper on bisphospho-nate—related osteonecrosis of the jaws -2009 update [J]. J OralMaxillofac Surg, 2009, 67(5 Suppl): 2-12.
  • 9Allen MR, Burr DB. The pathogenesis of bisphosphonate-relatedosteonecrosis of the jaw: so many hypotheses, so few data [J]. JOral Maxillofac Surg, 2009, 67(5 Suppl): 61-70.
  • 10McMahon RE, Bouquot JE, Glueck CJ, et al. Stagingbisphosphonate -related osteonecrosis of the jaw should includeearly stages of disease [J]. J Oral Maxillofac Surg, 2007,65(9):1899-1990.

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