乙型肝炎病毒准种的临床应用及其研究进展

Clinical application and research progress in hepatitis B virus quasispecies

准种现象普遍存在于RNA病毒中,乙型肝炎病毒(hepatitis B virus,HBV)虽属DNA病毒科,但同样存在准种现象,且其各编码区均可存在准种的特点.HBV在宿主体内是以准种的形式存在和分布的.变异与准种变迁密切相关,变异的多样性是准种产生的根本原因,是准种不断变迁的始动因素,变异的多样性和复杂性预示着准种的多样性和复杂性.HBV准种的变迁影响着患者的临床表现及对抗病毒药物的治疗反应,特别是准种的构成与抗病毒药物的耐药之间存在密切联系.引入准种,有助于我们从整体,动态的角度认识HBV,更加合理有效的预防、诊断和治疗HBV感染.

The phenomenon of quasispecies commonly exists in RNA virus. Although hepatitis B virus （HBV） is a kind of DNA virus, it has the same phenomenon. Moreover, every coding area of HBV has the characteristic of quasispecies. HBV exists and distributes in the form of quasispecies in hosts. The variation is closely related to the evolution of quasispecies. The diversity of variation is not only the fundamental reason for the generation of quasispecies, but also the initial factor of unceasing change in quasispecies, and the diversity and complexity of variation indicate those of quasispecies. The evolution of HBV quasispecies determines the patients＇ clinical manifestation and treatment response to antivirus drugs, and especially there is a close relationship between the composing of quasispecies and the resistance to antivirus drugs. The introduction of quasispecies can help us study HBV from the integral and dynamic angle and make a more reasonable prevention, diagnosis and treatment of HBV infection.