Vbeam脉冲染料激光治疗皮肤葡萄酒色斑的疗效分析

Therapeutic effect of Vbeam pulsed dye laser in the treatment of port wine stains

目的评价595nm Vbeam脉冲染料激光治疗皮肤葡萄酒色斑（Prot wine stains，PWS）的临床疗效。方法共114例PWS患者接受595nm Vbeam脉冲染料激光治疗，脉宽3—10ms，光斑直径7mm，能量密度10～15J／cm^2，动态冷却喷射30～40ms，间隔10—30ms，治疗间隔4～8周。根据皮损消退，将疗效分为4级：Ⅰ级为〉75％，Ⅱ级为50％～74％，Ⅲ级为25％～49％，Ⅳ级为〈25％。结果114例经过1～10次治疗（平均5．9次），取得很好临床效果，其中Ⅰ级74例（64．9％），Ⅱ级29例（25．4％），Ⅲ级9例（7．9％），Ⅳ级2例（1．8％）。并分析治疗次数、年龄大小、发生部位、颜色特点和疗效的关系，年龄小、发生于颈面部位、粉红型病损者疗效显著。随访6个月至2年，无复发，治疗部位无瘢痕形成。结论595nm波长Vbeam脉冲染料激光治疗皮肤PWS效果良好，并发症少，是目前一种很安伞、较可靠的治疗方法。

Objective To evaluate the clinical therapeutic effects of Vbeam 595 nm pulsed dye laser in 114 cases of port wine stains. Methods 114 patients with port wine stains were treated with Vbeam 595 nm pulsed dye laser with 3 - 10 ms pulse width and 7mm spot size. The energy fluence used varied from 10 to 15 J/cm^2. Dynamic cooling device （DCD） was used to protect epideim, with DCD spray 30 -40 ms and DCD delay 10 - 30 ms. The interval of therapy was 4 - 8 weeks. The results were graded on basis of cleaning and fading as follows： grade Ⅰ （ 〉 75% ）, grade Ⅱ （ 50 % to 74 % ）, grade Ⅲ （ 25 % to 49 % ）, and grade Ⅳ （ 〈 25 % ） o Results 114 patients completed the therapy. The number of treatments ranged from 1 to 10 （ mean 5.9 ）. The results evaluated as grades Ⅰ , Ⅱ,Ⅲ and Ⅳ were 74 patients （64.9 % ）, 29 patients （25.4 % ） ,9 patients （7.9 % ） and 2 patients （ 1.8 % ）, respectively. The therapeutic effect was analysed according to number of treatments, the ages of patients, site and color of the lesions. It was found that the therapeutic effect was prominent in patients of younger age, with pink lesions located on the neck and face. No recurrence and scar happened after 6 months to 2 years follow-up. Conclusions Vbeam 595nm pulsed dye laser is a safe and effective method for the treatent of port wine stains, with less complications.