河南省肝癌危险因素的病例对照研究

Carcinoma in Henan Province A Case-Control Study of Risk Factors for Hepatocellular

为了确定河南省肝癌发病的危险因素,选择152例诊断明确的原发性肝癌住院病例作为病例组,同时选择115例非肝病住院病例(排除肝胆系统疾患)作为对照组,进行病例对照研究。结果表明,HBV感染是河南省肝癌发病的重要危险因素(OR=31.22);HCV单独致肝癌的OR值为2.57,95％可信限为0.57～12.03,无统计学意义。但当HCV和HBV同时存在时,OR值为42.85,明显高于HBV或HCV单独致肝癌的危险性,呈明显的协同作用或相加作用。采用非条件Logistic回归模型分析表明HBV感染、本人肝病史、家庭肝病史、饮酒史,长期食用玉米、花生及花生类制品和精神创伤史等因素与肝癌发病有关联。

In order to determine the risk factors in the development of hepatocellular carcinoma ( HCC) in Henan, China, a case-control study of 152 HCC patients and 115 controls with non-hepatic diseases was carried out. The single factor analysis indicated that HBV and HCV infections were the important risk factors for HCC in Henan, China with the odds ratio (OR)of 31.22 and 2.57, respectively. The risk of HCC in creased significantly and showed an additive effect in patients with HBV and HCVcoinfection (OR= 42. 85). The unconditional logistic regression model for the multivari-ate analysis showed that history of liver disease, history of alcohol drinking, dietary aflatoxin intake (corn, peanut and peanut oil consumption) , psychosocial factor and HBV infection were considered to be the risk factors in the development of HCC in Henan, China.