肝衰竭肝细胞凋亡和膨胀性坏死分子机制研究进展
被引量:2
摘要
肝衰竭是一种重症肝病,可由不同原因引发,但归根结底表现为肝细胞和肝脏内其他类型细胞的过度死亡,因此充分了解肝细胞死亡的分子机制,为肝衰竭的发生、发展以及治疗提供依据有着重大意义。近年来关于细胞死亡的细胞内信号转导机制研究已取得了很大进展。其中被公认的肝细胞死亡方式有二类,一是“自毁”式细胞死亡,即细胞凋亡;一是“被毁”式细胞死亡,即膨胀性坏死。
出处
《传染病信息》
2008年第2期74-77,共4页
Infectious Disease Information
参考文献29
-
1Krammer PH. CD95' s deadly mission in the immune system[J]. Nature,2000,407(6805):789-795.
-
2Danial NN, Korsmeyer SJ. Cell death: critical control points [J]. Cell, 2004,16(2): 205 -219.
-
3Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis[J]. Hepatology,2004,39(2):273-278.
-
4Lavrik I, Golks A, Krammer PH. Death receptor signaling[J]. J Cell Sci,2005,118(Pt 2):265-267.
-
5Li S, Zhao Y, He X, et al. Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis[J]. J Biol Chem,2002, 277(30):26912-26920.
-
6Henning SB, Marcus S, Binje F, et al. The role of apoptosis versus oncotic necrosis in liver injury:facts or faith?[J]. J Hepatol,2006,44(5):984-993.
-
7Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX and BAK:a requisite gateway to mitochondrial dysfunction and death[J]. Science,2001,292(5517):727-730.
-
8Hatano E, Bradham CA, Stark A, et al. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes[J]. J Biol Chem,2000,275 (16): 11814- 11823.
-
9Crompton M, Virji S, Ward JM. Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore[J]. Eur J Biochem 1998,258(2):729-735.
-
10Hengartner MO. The biochemistry of apoptosis[J]. Nature, 2000,407(6805):770-776.
二级参考文献4
-
1朱克顺,中华实验和临床病毒学杂志,1997年,11卷,336页
-
2胡瑾华,中华实验和临床病毒学杂志,1998年,12卷,64页
-
3朱克顺,张玲霞,王惠芬,王松山,王林杰,潘庆联.Fas介导的细胞凋亡在乙型肝炎肝组织中分布状况初探[J].中华实验和临床病毒学杂志,1997,11(4):336-339. 被引量:4
-
4胡瑾华,张玲霞,王慧芬,王松山,王林杰.慢性乙型肝炎肝组织FasL的免疫组化研究[J].中华实验和临床病毒学杂志,1998,12(1):64-66. 被引量:7
共引文献7
-
1陈二军.苦参素注射液联合中药治疗慢性乙型病毒性肝炎疗效观察[J].河北中医,2007,29(9):836-837. 被引量:1
-
2陈小文,樊国强.苦参碱注射液治疗慢性乙型肝炎效果分析[J].南华大学学报(医学版),2006,34(4):601-603. 被引量:3
-
3向晓星,王国俊,蔡雄,李玉莉.氧化苦参碱对小鼠暴发型肝衰竭的保护作用[J].临床肝胆病杂志,2000,16(2):92-93. 被引量:46
-
4邵润轩,王江滨,王宵伟.凋亡相关因子Fas/FasL在慢性肝炎、原发性肝癌表达的规律[J].世界华人消化杂志,2000,8(8):937-939. 被引量:10
-
5周海珍.中医治疗慢性乙肝52例疗效观察[J].中医临床研究,2015,7(6):72-74. 被引量:1
-
6陆宁,赵湖珊.苦参素联合中药治疗慢性乙肝疗效观察[J].辽宁中医杂志,2003,30(1):38-39. 被引量:3
-
7付玉山,李东湖,李启义.中药联合苦参素治疗慢性乙型病毒性肝炎[J].湖北中医杂志,2004,26(5):31-32. 被引量:5
同被引文献35
-
1Xue-Zhang Duan,Fang-Fang Liu,Jing-Jing Tong,Hao-Zhen Yang,Jing Chen,Xiao-Yan Liu,Yuan-Li Mao,Shao-Jie Xin,Jin-Hua Hu.Granulocyte-colony stimulating factor therapy improves survival in patients with hepatitis B virus-associated acuteon-chronic liver failure[J].World Journal of Gastroenterology,2013,19(7):1104-1110. 被引量:36
-
2徐旭雯,谭德明,鲁猛厚.粒细胞集落刺激因子对小鼠急性肝衰竭的保护作用[J].中南大学学报(医学版),2006,31(4):543-547. 被引量:8
-
3Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association.肝衰竭诊疗指南[J].中华肝脏病杂志,2006,14(9):643-646. 被引量:829
-
4Kass CE. Mitochondrial involvement in drug-induced hepatic injury [ J ] . Chem Biol Interact, 2006, 163 ( 1-2 ) : 145-159.
-
5Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death [ J ] . Physiol Rev, 2007, 87 ( 1 ) : 99-163.
-
6Kroemer G, Reed JC. Mitochondrial control of cell death [ J ] . Nat Med, 2000, 6 (5): 513-519.
-
7Kokoszka JE, Waymire KG, Levy SE, et al. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore [ J ] . Nature, 2004, 427 ( 6973 ) : 461-465.
-
8Bernardi P, Krauskopf A, Basso E, et al. The mitochondrial permeability transition from in vitro artifacts to disease target [ J ] . FEBSJ, 2006, 273 (10) : 2077-2099.
-
9Crichton PG, Parker N, Vidal-Puig A J, et al. Not all mitochondrial carrier proteins support permeability transition pore formation : no involvement of uncoupling protein [ J ] . Biosci Rep, 2009, 30 ( 3 ): 187-192.
-
10Devinney MJ, Malaiyandi LM, Vergun O, et al. A compariso of Zn2+- and Ca2+-triggered depolarization of liver mitochondri reveals no evidence of Zn2+-induced permeability transition [ J ] CellCaleium, 2009, 45 (5): 447-455.
二级引证文献2
-
1王圣明,拜云虎,吴菲菲,王东辉,王嘉琪,戴春秋,杨雁灵,王亚云.急性肝衰竭小鼠线粒体分裂蛋白DRP1在肝脏和大脑皮层的表达变化[J].神经解剖学杂志,2017,33(3):311-316. 被引量:1
-
2张燕燕,秦百君,陈月桥,卫家润,裴浩,李坚宇,张雪.解毒化瘀颗粒治疗急性肝衰竭的研究进展[J].广西医学,2023,45(24):3038-3041.
-
1黄坤,胡瑾华.JNK在肝功能衰竭发病机制中的作用[J].肝脏,2010,15(4):303-305.
-
2陈秋华.重型肝炎58例的护理[J].中国误诊学杂志,2012,12(15):4108-4108.
-
3唐永煌,肖锡昌.风湿性疾病与肝损害(附5例报告)[J].广东医学,1994,15(9):643-643.
-
4赵非一,王梓,燕海霞.哮喘防复发,把握发作前的“时间窗”[J].自我保健,2014,0(10):35-35.
-
5郭春艳,韩波.细胞凋亡与心肌炎发病机制的关系及抗细胞凋亡的研究进展[J].中国实用儿科杂志,2006,21(4):310-312. 被引量:1
-
6闫磊.胰腺癌细胞凋亡相关基因的研究进展[J].牡丹江医学院学报,2006,27(3):63-64. 被引量:1
-
7廖美焱,水华,周秀芳,陈惠祯.顺铂引起卵巢癌细胞周期变化及凋亡的观察[J].武汉大学学报(医学版),2001,22(4):314-316. 被引量:1
-
8肖恩华.细胞凋亡与肝癌[J].国外医学(临床放射学分册),1999,22(1):9-12. 被引量:3
-
9贺大林,李磊.根治性放疗和根治性手术对于早期前列腺癌孰优孰劣[J].现代泌尿外科杂志,2013,18(4):394-394. 被引量:1
-
10李绍强,梁力建,黄洁夫,李智.肝细胞凋亡在肝硬化大鼠肝缺血再灌注损伤中的意义[J].中华肝胆外科杂志,2002,8(11):674-677. 被引量:8